We partially accept this recommendation. 55. UKRI has strong international relationships including with Dutch colleagues NWO and look forward to learning more about their pilot programme, and whether it has brought about intended outcomes. 56. UKRI has a diverse portfolio of funding mechanisms, inclusive of replication studies, meta-analysis and longer-term grants. UKRI requests additional specific information for reproducibility in areas where there is increased concern, such as the use of animals in research where the 3R’s apply (replacement, reduction and refinement). 57. As described above, In June 2023 UKRI launched the £7 million Innovation and Research Caucus20 (IRC) as a world leading centre of excellence to maximise research and innovation funding impact and will consider the case for further increasing focus on metascience. 58. UKRI funds research across all disciplines. The desirability, possibility and practicality of reproducing results varies greatly across the work that UKRI funds. For example, in some areas where experimental cycles are short, reproducibility is inherently built into any project funding, and in many disciplines, robustness is further enhanced by taking multiple different approaches to test the same hypothesis.