1
Acknowledged
Robust clinical trial data lacking for long-term phage safety and immune interactions
Conclusion
The safety of phages has been well established mainly on the basis of observational evidence drawn from specific clinical interventions. However, as with all medicines, robust clinical trial data is important to provide and develop assurances around all aspects of patient safety, including the long-term impact of phages, especially their interaction with human immune systems, such as anaphylaxis and auto immune response.
Government Response Summary
The government outlined ongoing engagement with phage stakeholders and monitoring of the research and clinical trial pipeline. It stated the upcoming 2024-2029 AMR National Action Plan will set out research priorities, including innovation for AMR.
Paragraph Reference
39
Government Response
Acknowledged
Government Response
Acknowledged
HM Government
Acknowledged
The government will continue to engage with phage stakeholders, including through the Innovate UK Knowledge Transfer Network (KTN) Phage Innovation Network. The UK Health Security Agency (UKHSA) provides the chair for Phage Innovation Network’s scientific advisory board. UKHSA supports the goals of the network in developing phage- based products for use in clinical settings and other sectors, alongside developing links with researchers. The MHRA is working closely with the network to understand how it can support phage research and innovation. DHSC works closely with NIHR and UK Research and Innovation (UKRI) to monitor the research and clinical trial pipeline for antimicrobials and alternative therapies. Where phage research opportunities are identified, NIHR can engage researchers to encourage and support funding applications. The government is developing the 2024 to 2029 AMR NAP. The NAP will set out the government's research priorities, including innovation of new products for tackling AMR.
Source
Report
First Report - The antimicrobial potential of bacteriophages
03 Jan 2024
HC 328
Addressee Bodies
Department for Science, Innovation and Technology
Timeline
Recommendation age
2.4 yrs
Report published
03 Jan 2024