32 Rejected

Government and agency statements on phage role in AMR lack clarity.

Recommendation
If the antimicrobial use of phages is to move beyond ad hoc compassionate cases, the Government and its agencies should reflect on what role they are to play in the fight against AMR. At the moment, phages are referred to in the AMR strategy, as one approach amongst others. However, we believe that the Government and its agencies should make a more definitive and positive statement on phages. Clarity is imperative for research funding decisions and for private investment in commercial phages.
Government Response Summary
The government rejects producing a further definitive statement on phages or a roadmap at this time, stating it will continue to monitor developments and include phages as one of many research areas in the upcoming AMR national action plan.
Paragraph Reference
140
Government Response
Rejected
HM Government Rejected
The government previously set out its position on the use of phages to tackle AMR in the written evidence that was submitted to the inquiry in April 2023 (10). This reaffirmed the government commitment to exploring phage therapy as an alternative to antibiotics. While current evidence on phage therapy is promising, more robust data is required to fully understand the role phages could play in combatting AMR. The government continues to work closely with partners to understand, and support, the growing evidence base for bacteriophage therapy. The government is developing the 2024 to 2029 AMR national action plan (NAP). The NAP will recognise the importance of exploring a range of different research areas, including phages, to develop a comprehensive therapeutic suite for treating and managing infections in humans and animals. There are several barriers to the development and deployment of phage therapy including quality assurance, supply chain adequacy, financial approvals, health, safety and containment, and usage guidelines, some of which were highlighted in the committee’s report and by contributors to this paper. The government will not produce a further statement on its assessment of phages at this time or publish a roadmap that depicts how phage manufacture and regulation will be embedded in the UK. The government will continue to seek, monitor and evaluate developments made in phage therapy research and use of phage therapies as part of reviewing progress on the wider government AMR programme.
Addressee Bodies
Department for Science, Innovation and Technology
Timeline
Recommendation age 2.4 yrs
Report published 03 Jan 2024