Paolino Amico
PFD Report
All Responded
Ref: 2025-0585
All 2 responses received
· Deadline: 12 Jan 2026
Coroner's Concerns (AI summary)
Multiple serious medication errors, including non-administration of pain relief and prescription mistakes, occurred. There were also critical failures in the discharge plan for oxygen and delays in escalating a deteriorating patient's condition.
View full coroner's concerns
(1) The consultant required a discharge plan for oxygen therapy to be in place before Mr Amico could go home. The hospital discharge plan and medications were confusing and the referral for oxygen therapy requirement was unclear, and the PAT testing for the machine was out of date. Paramedics advised the family that the oxygen provided on Mr Amico’s discharge was low flow and was not meeting his oxygen requirements with his oxygen saturations at 68% and this immediately improved on ambulance crew equipment.
(2) Mr Amico did not receive his prescribed medications during his second admissions when he was readmitted to hospital on 9 June.
a. On 9 June a doctor in Accident & Emergency had reviewed Mr Amico’s prescribed medications and increased liquid oral morphine sulphate 10 mg in 5mL Solution 4 hourly as required with 2.5 -5 mg max 6 doses at 22:57 hours with slow released morphine sulphate (MST) continued 2 times daily. Trust staff did not administer any morphine to Mr Amico although he and his family were raising concerns about his high level of pain.
b. The family was informed incorrectly that medications had not been prescribed. On the morning of 10 June, the family were given permission by a nurse to dispense from Mr Amico’s own supply of medications that he had brought to the hospital due to his level of pain. This was not accurately recorded in Mr Amico’s record. Mr Amico took his prescribed morning dose of MST.
c. On 10 June the nurse in Accident & Emergency did not escalate to the nurse in charge or a senior doctor that she could not locate the doctor allocated to Mr Amico and instead approached a foundation year 1 doctor to prescribe pain relief for Mr Amico. The nurse informed the doctor who was junior and very busy that the frequency of the morphine needed to be increased for Mr Amico. The doctor did not escalate the matter and did not review Mr Amico before prescribing a controlled drug.
d. Neither the nurse nor the doctor sufficiently scrutinised the medication prescribed on 9 June or on the Trust system that would have shown the correct medications. This led to a prescription error being made with MST being increased from 2 times daily to 4 times daily. Mr Amico was not referred for pain management.
e. Mr Amico then moved to a ward. Multiple nurses were involved in checking and administering a controlled drug morphine sulphate slow release (MST) on 5 separate occasions between 10 and 11 June 2024 and did not raise concerns about the potential for a prescription error or note that Mr Amico had already received 1 dose of MST that morning.
(3) Mr Amico’s NEWS score increased, and an emergency call was not put out on 11 June when it was established that Mr Amico was unresponsive even to pain from 03:00 hours .
(4) The on-call doctor was called approximately one hour after Mr Amico’s NEWS score was found to be 10 and arrived at 07:50, this was not an emergency call. The on-call doctor had not been informed of:
a. the deterioration in Mr Amico’s presentation during the night
b. that the family had informed nursing staff of their concerns Mr Amico had been given the wrong medication when he was noted to be unresponsive at approximately 03:00 hours, that should have immediately raised concerns about an overdose of MST.
(5) The on-call doctor escalated concerns immediately but not emergency call was put out.
(6) Mr Amico morphine overdose was partially treated:
a. There was an immediate response to Naloxone but the opioid reversal for overdose was not in accordance with British National Formulary guidelines or with an NHS England alert previously issued.
b. There was no consideration or plan for alternative pain management in a patient who had been receiving morphine pain relief as part of his treatment plan for cancer.
c. Mr Amico suffered acute withdrawal syndrome and family complained about his suffering to hospital staff that they stated was not ameliorated. An emergency call would have triggered the attendance of an Anaesthetist who could have given advice on opioid reversal in a palliative patient. Princess Alexandra Hospital & NHS England (7) Multiple nurses were involved in morphine administration and all had completed their original training outside of the UK and had undertaken a Trust medicines administration training that should have recognised that the prescription of MST 4 times a day was not appropriate. Mr Amico received 6 doses of MST in less than 24 hours instead of 2.
(8) Medicines administration refresher training for nurses is not mandatory and the Trust in reviewing this case has not followed a local recommendation from senior nurses for this to be included.
(2) Mr Amico did not receive his prescribed medications during his second admissions when he was readmitted to hospital on 9 June.
a. On 9 June a doctor in Accident & Emergency had reviewed Mr Amico’s prescribed medications and increased liquid oral morphine sulphate 10 mg in 5mL Solution 4 hourly as required with 2.5 -5 mg max 6 doses at 22:57 hours with slow released morphine sulphate (MST) continued 2 times daily. Trust staff did not administer any morphine to Mr Amico although he and his family were raising concerns about his high level of pain.
b. The family was informed incorrectly that medications had not been prescribed. On the morning of 10 June, the family were given permission by a nurse to dispense from Mr Amico’s own supply of medications that he had brought to the hospital due to his level of pain. This was not accurately recorded in Mr Amico’s record. Mr Amico took his prescribed morning dose of MST.
c. On 10 June the nurse in Accident & Emergency did not escalate to the nurse in charge or a senior doctor that she could not locate the doctor allocated to Mr Amico and instead approached a foundation year 1 doctor to prescribe pain relief for Mr Amico. The nurse informed the doctor who was junior and very busy that the frequency of the morphine needed to be increased for Mr Amico. The doctor did not escalate the matter and did not review Mr Amico before prescribing a controlled drug.
d. Neither the nurse nor the doctor sufficiently scrutinised the medication prescribed on 9 June or on the Trust system that would have shown the correct medications. This led to a prescription error being made with MST being increased from 2 times daily to 4 times daily. Mr Amico was not referred for pain management.
e. Mr Amico then moved to a ward. Multiple nurses were involved in checking and administering a controlled drug morphine sulphate slow release (MST) on 5 separate occasions between 10 and 11 June 2024 and did not raise concerns about the potential for a prescription error or note that Mr Amico had already received 1 dose of MST that morning.
(3) Mr Amico’s NEWS score increased, and an emergency call was not put out on 11 June when it was established that Mr Amico was unresponsive even to pain from 03:00 hours .
(4) The on-call doctor was called approximately one hour after Mr Amico’s NEWS score was found to be 10 and arrived at 07:50, this was not an emergency call. The on-call doctor had not been informed of:
a. the deterioration in Mr Amico’s presentation during the night
b. that the family had informed nursing staff of their concerns Mr Amico had been given the wrong medication when he was noted to be unresponsive at approximately 03:00 hours, that should have immediately raised concerns about an overdose of MST.
(5) The on-call doctor escalated concerns immediately but not emergency call was put out.
(6) Mr Amico morphine overdose was partially treated:
a. There was an immediate response to Naloxone but the opioid reversal for overdose was not in accordance with British National Formulary guidelines or with an NHS England alert previously issued.
b. There was no consideration or plan for alternative pain management in a patient who had been receiving morphine pain relief as part of his treatment plan for cancer.
c. Mr Amico suffered acute withdrawal syndrome and family complained about his suffering to hospital staff that they stated was not ameliorated. An emergency call would have triggered the attendance of an Anaesthetist who could have given advice on opioid reversal in a palliative patient. Princess Alexandra Hospital & NHS England (7) Multiple nurses were involved in morphine administration and all had completed their original training outside of the UK and had undertaken a Trust medicines administration training that should have recognised that the prescription of MST 4 times a day was not appropriate. Mr Amico received 6 doses of MST in less than 24 hours instead of 2.
(8) Medicines administration refresher training for nurses is not mandatory and the Trust in reviewing this case has not followed a local recommendation from senior nurses for this to be included.
Responses
Action Taken
NHS England's Regional Chief Nurse is overseeing a system-wide review with the provider trust, looking at medication safety incidents and clinical incidents. The Patient Safety Group has strengthened leadership challenge and is monitoring medicines safety and deterioration. (AI summary)
NHS England's Regional Chief Nurse is overseeing a system-wide review with the provider trust, looking at medication safety incidents and clinical incidents. The Patient Safety Group has strengthened leadership challenge and is monitoring medicines safety and deterioration. (AI summary)
View full response
Dear Coroner, Re: Regulation 28 Report to Prevent Future Deaths – Paolino Amico who died on 12 June 2024.
Thank you for your Report to Prevent Future Deaths (hereafter “Report”) dated 17 November 2025 concerning the death of Paolino Amico on 12 June 2024. In advance of responding to the specific concerns raised in your Report, I would like to express my deep condolences to Paolino’s family and loved ones. NHS England is keen to assure the family and yourself that the concerns raised about Paolino’s care have been listened to and reflected upon.
I am grateful for the further time granted to respond to your Report, and I apologise for any anguish this delay may have caused to Paolino’s family or friends. I realise that responses to Coroners’ Reports can form part of the important process of family and friends coming to terms with what has happened to their loved ones, and I appreciate this will have been an incredibly difficult time for them.
Your Report raises concerns around morphine administration involving multiple nurses, who had all completed their original training outside of the UK and had undertaken a Trust’s medicines administration training. Such training should have enabled the nurses to recognise that the prescription of morphine sulphate (MST) was inappropriate, and that there had been a prescription error leading to multiple overdoses of MST. You also raised that medicines administration refresher training for nurses is not mandatory.
Inaccurate or incomplete recording of medication in the patient’s records
Nurses, as key members of the healthcare team, play a vital role in the administration, monitoring and documentation of medication. It is difficult to ascertain from this specific case and the information available what specific systems and other contributory factors may have hindered the nurse in the Emergency Department (ED) from documenting or scrutinising the administration of MST, noting the fast paced and busy ED environment.
National Medical Director NHS England Wellington House 133-155 Waterloo Road London SE1 8UG
20th January 2026
Evidence and published research highlights that distractions and interruptions cause memory lapses and task omissions, and are recognised factors leading to nurses forgetting to document care and potentially leading to omissions of care. Documentation is guided by the rights of medication administration and regulatory standards set by bodies like the Nursing and Midwifery Council (NMC) and Care Quality Commission (CQC).
Contemporaneous patient medical records must be completed at the time of administration to avoid errors, and the practitioner administering the medication is accountable for their actions. To ensure high standards of care, the NMC has established comprehensive guidelines and standards for medicines management.
Inappropriate escalation to the junior doctor for prescribing pain relief
Your Report raises concerns around the ED nurse approaching a foundation year 1 doctor to prescribe pain relief, rather than escalating to the nurse in charge or a senior doctor. Evidence and published literature recognises that human factors such as workload, fatigue and competing priorities can contribute to errors in clinical practice; therefore supporting our workforce in these and other settings is essential to improving patient safety.
Year 1 foundation doctors can prescribe medication, under supervision. It may be that the nurse was not aware of this and assumed that the doctor would have asked a more senior doctor to check and sign off on the medication prescription.
Medication error and scrutinising the prescription
Your Report also raises concerns around the prescription error and lack of scrutiny, despite multiple nurses being involved in checking and administering a controlled drug. Administering medicines is a high risk task in healthcare and medication checks are critical to prevent errors (defined as any mistake in the prescribing, dispensing, administering or monitoring of medicines).
Annually, an estimated 237 million medication errors occur with administration and prescribing being the most common. Of this 66 million are potentially clinically significant errors.. In line with the National Patient Safety strategy, healthcare providers must be committed to minimising risk and harm to patients and, to ensure safety, the NHS is using a Just and Learning Culture approach which involves identifying the causes of errors and learning from them.
Registered nurses are expected to scrutinise prescriptions, ensuring that they are legible, valid and appropriate for the patient before administration. This includes checking the patient’s identity, the medicine name, dose, route and timing as well as confirming that the prescription complies with legal requirements, particularly for controlled drugs. However, as stated above, based on the information available it is difficult to ascertain what system factors may have contributed to the medication errors in Paolino’s case.
Controlled drugs must be administered in strict accordance with policy, usually requiring a second registered nurse to witness preparation and administration, with
both signatures recorded in the controlled drugs register. National Institute for Health and Care Excellence (NICE) medicines optimisation guidance (NG 5, 2015) emphasises the need for robust systems to verify prescriptions and prevent avoidable harm. When multiple nurses check a controlled drug but fail to identify an error, this highlights a breakdown in the safety system such as clinical oversight of prescribing by pharmacists. The Royal College of Emergency Medicines and UK Clinical Pharmacy Association have issued a joint statement on the benefits of pharmacy support to emergency departments.
NHS England offers support to providers to improve the safe use of controlled drugs. NHS Trusts must appoint a Controlled Drugs Accountable Officer and a Medication Safety Officer. Their remits differ however both have a duty to ensure the safe use of opioids in their organisations. NHS England operates networks for both groups to receive and spread the learning from errors. We also offer guidance and tools to enable NHS Trusts to effectively learn from patient safety incidents through the Patient Safety Incident Response Framework. We note that the Patient Safety Incident Response Plan for the Princess Alexandra Hospital includes workstreams to improve safety in ED, in Medicines management, controlled drugs and medicines reconciliation
Failure to escalate National Early Warning Score (NEWS)
When a patient’s NEWS score reaches 10, this represents a critical level of physiological deterioration requiring an urgent medical response. Providers will have local policies and Standard Operating Procedures (SOP) in place for the safe and effective management of this. This information would be important to ensure lessons are learnt and the risks of reoccurrence are mitigated.
NEWS was developed by the Royal College of Physicians in 2012, aimed at standardising the process for recording, scoring and responding to changes in routinely measured physiological parameters in acutely unwell patients, and to support the reliable recognition and response to acute deterioration. The guidance is clear that scores as high as 10 mandate an immediate urgent call to a senior doctor or the rapid response team. Registered nurses are professionally accountable under the NMC Code to ‘Raise concerns immediately if you believe a person is at risk.’ It is recognised that a failure to escalate promptly in these circumstances places the patient at significant risk of harm.
Documentation must also reflect the NEWS score, the actions taken and the time of escalation, ensuring transparency and accountability.
Overdosing medication
It is disappointing that, despite multiple nurses checking and administering a controlled drug on 5 separate occasions between 10 and 11 June 2024, it did not raise concerns about the potential for a prescription error, nor was it noted that Paolino had already received 1 dose of MST that morning. As above, when multiple nurses check a controlled drug but fail to identify an error, this highlights a breakdown in the safety system such as a lack of an independent double checking process. Registered nurses are expected to exercise vigilance when scrutinising prescriptions and preparing medicines, ensuring that doses are correct and appropriate for the patient. The NMC
Code requires nurses to ‘preserve safety’ and ‘practise effectively’, which includes preventing harm through careful checking and adherence to local medicines management policies.
Lack of mandatory refresher training
Registered nurses are expected to maintain up-to-date knowledge and competence in medicines management through initial training and regular refresher programmes. The NMC Code requires nurses to ‘keep your knowledge and skills up to date’ and to practise safely by recognising the limits of their competence.
The NICE medicines optimisation guidance NG 5 (2015) referenced above recommends that organisations support healthcare professionals through training and education to ensure safe prescribing, dispensing and administration. In this specific case, education and training alone would not prevent these types of safety system issues and would not be sufficient to mitigate the risk of reoccurrence. Systems improvements and mechanisms will need to be implemented to ensure lessons are learnt and that the current organisational and systems factors and processes highlighted in this case are addressed, to ensure the safe and effective checking and administration of medications. This has been substantiated by safety research and incident analysis.
The Royal College of Nursing guidance emphasises that medicines administration training should be refreshed periodically to ensure familiarity with current legislation, local policies and best practice in areas such as controlled drugs, high risk medicines, and safe prescribing. Refresher training also reinforces the importance of double checking, accurate documentation and escalation procedures when errors or adverse reactions occur.
Local Actions The Princess Alexandra Hospital NHS Trust will be providing their own response to this Report, however, the Hertfordshire & West Essex ICB have advised NHS England of the Trust’s governance arrangements and actions being taken to address the concerns raised. It is understood that the Trust’s Patient Safety Group (PSG) has active oversight of several of the areas highlighted in the Report, particularly medicines safety, recognition of deterioration, and incident learning. Medicines safety is a standing agenda item at their PSG, supported by the Medicines Optimisation Group and Medication Safety Officer, with regular review of prescribing and administration incidents, controlled drugs governance, and training compliance. The PSG has recognised gaps in training uptake and has been sighted on system- level behaviours through its routine oversight of medicines safety and incident learning. Themes PSG have been sighted on include:
• Variable engagement with medicines safety processes, such as inconsistent uptake of medicines management training and variation in adherence to medicines administration standards.
• Inconsistent escalation behaviours, for example delays in escalating concerns or delays in closing incidents and embedding learning.
• Operational pressures influencing practice, such as missed opportunities to scrutinise prescriptions or incomplete discharge processes.
• Variation in response to clinical or governance challenge, where concerns about documentation or compliance have not always been acted on promptly. PSG has strengthened leadership challenge, required divisional action plans where compliance is low, and continues to monitor medicines safety, controlled drugs governance and deterioration as standing agenda items.” Recognition and escalation of deteriorating patients is overseen through the Deteriorating Patient Group, with additional mitigation introduced via 12-hour harm reviews in urgent care settings to examine escalation, observations and clinical response. The PSG has also strengthened its focus on timely incident closure and learning, with senior leadership challenges and actions in place to ensure serious incidents are reviewed, learning is embedded, and assurance is provided through the Quality & Safety Committee and Trust Board. I would also like to provide further assurances on the national NHS England work taking place around the Reports to Prevent Future Deaths. All reports received are discussed by the Regulation 28 Working Group, comprising Regional Medical Directors, and other clinical and quality colleagues from across the regions. This ensures that key learnings and insights around events, such as the sad death of Paolino, are shared across the NHS at both a national and regional level and helps us to pay close attention to any emerging trends that may require further review and action.
Thank you for bringing these important patient safety issues to my attention and please do not hesitate to contact me should you need any further information.
Thank you for your Report to Prevent Future Deaths (hereafter “Report”) dated 17 November 2025 concerning the death of Paolino Amico on 12 June 2024. In advance of responding to the specific concerns raised in your Report, I would like to express my deep condolences to Paolino’s family and loved ones. NHS England is keen to assure the family and yourself that the concerns raised about Paolino’s care have been listened to and reflected upon.
I am grateful for the further time granted to respond to your Report, and I apologise for any anguish this delay may have caused to Paolino’s family or friends. I realise that responses to Coroners’ Reports can form part of the important process of family and friends coming to terms with what has happened to their loved ones, and I appreciate this will have been an incredibly difficult time for them.
Your Report raises concerns around morphine administration involving multiple nurses, who had all completed their original training outside of the UK and had undertaken a Trust’s medicines administration training. Such training should have enabled the nurses to recognise that the prescription of morphine sulphate (MST) was inappropriate, and that there had been a prescription error leading to multiple overdoses of MST. You also raised that medicines administration refresher training for nurses is not mandatory.
Inaccurate or incomplete recording of medication in the patient’s records
Nurses, as key members of the healthcare team, play a vital role in the administration, monitoring and documentation of medication. It is difficult to ascertain from this specific case and the information available what specific systems and other contributory factors may have hindered the nurse in the Emergency Department (ED) from documenting or scrutinising the administration of MST, noting the fast paced and busy ED environment.
National Medical Director NHS England Wellington House 133-155 Waterloo Road London SE1 8UG
20th January 2026
Evidence and published research highlights that distractions and interruptions cause memory lapses and task omissions, and are recognised factors leading to nurses forgetting to document care and potentially leading to omissions of care. Documentation is guided by the rights of medication administration and regulatory standards set by bodies like the Nursing and Midwifery Council (NMC) and Care Quality Commission (CQC).
Contemporaneous patient medical records must be completed at the time of administration to avoid errors, and the practitioner administering the medication is accountable for their actions. To ensure high standards of care, the NMC has established comprehensive guidelines and standards for medicines management.
Inappropriate escalation to the junior doctor for prescribing pain relief
Your Report raises concerns around the ED nurse approaching a foundation year 1 doctor to prescribe pain relief, rather than escalating to the nurse in charge or a senior doctor. Evidence and published literature recognises that human factors such as workload, fatigue and competing priorities can contribute to errors in clinical practice; therefore supporting our workforce in these and other settings is essential to improving patient safety.
Year 1 foundation doctors can prescribe medication, under supervision. It may be that the nurse was not aware of this and assumed that the doctor would have asked a more senior doctor to check and sign off on the medication prescription.
Medication error and scrutinising the prescription
Your Report also raises concerns around the prescription error and lack of scrutiny, despite multiple nurses being involved in checking and administering a controlled drug. Administering medicines is a high risk task in healthcare and medication checks are critical to prevent errors (defined as any mistake in the prescribing, dispensing, administering or monitoring of medicines).
Annually, an estimated 237 million medication errors occur with administration and prescribing being the most common. Of this 66 million are potentially clinically significant errors.. In line with the National Patient Safety strategy, healthcare providers must be committed to minimising risk and harm to patients and, to ensure safety, the NHS is using a Just and Learning Culture approach which involves identifying the causes of errors and learning from them.
Registered nurses are expected to scrutinise prescriptions, ensuring that they are legible, valid and appropriate for the patient before administration. This includes checking the patient’s identity, the medicine name, dose, route and timing as well as confirming that the prescription complies with legal requirements, particularly for controlled drugs. However, as stated above, based on the information available it is difficult to ascertain what system factors may have contributed to the medication errors in Paolino’s case.
Controlled drugs must be administered in strict accordance with policy, usually requiring a second registered nurse to witness preparation and administration, with
both signatures recorded in the controlled drugs register. National Institute for Health and Care Excellence (NICE) medicines optimisation guidance (NG 5, 2015) emphasises the need for robust systems to verify prescriptions and prevent avoidable harm. When multiple nurses check a controlled drug but fail to identify an error, this highlights a breakdown in the safety system such as clinical oversight of prescribing by pharmacists. The Royal College of Emergency Medicines and UK Clinical Pharmacy Association have issued a joint statement on the benefits of pharmacy support to emergency departments.
NHS England offers support to providers to improve the safe use of controlled drugs. NHS Trusts must appoint a Controlled Drugs Accountable Officer and a Medication Safety Officer. Their remits differ however both have a duty to ensure the safe use of opioids in their organisations. NHS England operates networks for both groups to receive and spread the learning from errors. We also offer guidance and tools to enable NHS Trusts to effectively learn from patient safety incidents through the Patient Safety Incident Response Framework. We note that the Patient Safety Incident Response Plan for the Princess Alexandra Hospital includes workstreams to improve safety in ED, in Medicines management, controlled drugs and medicines reconciliation
Failure to escalate National Early Warning Score (NEWS)
When a patient’s NEWS score reaches 10, this represents a critical level of physiological deterioration requiring an urgent medical response. Providers will have local policies and Standard Operating Procedures (SOP) in place for the safe and effective management of this. This information would be important to ensure lessons are learnt and the risks of reoccurrence are mitigated.
NEWS was developed by the Royal College of Physicians in 2012, aimed at standardising the process for recording, scoring and responding to changes in routinely measured physiological parameters in acutely unwell patients, and to support the reliable recognition and response to acute deterioration. The guidance is clear that scores as high as 10 mandate an immediate urgent call to a senior doctor or the rapid response team. Registered nurses are professionally accountable under the NMC Code to ‘Raise concerns immediately if you believe a person is at risk.’ It is recognised that a failure to escalate promptly in these circumstances places the patient at significant risk of harm.
Documentation must also reflect the NEWS score, the actions taken and the time of escalation, ensuring transparency and accountability.
Overdosing medication
It is disappointing that, despite multiple nurses checking and administering a controlled drug on 5 separate occasions between 10 and 11 June 2024, it did not raise concerns about the potential for a prescription error, nor was it noted that Paolino had already received 1 dose of MST that morning. As above, when multiple nurses check a controlled drug but fail to identify an error, this highlights a breakdown in the safety system such as a lack of an independent double checking process. Registered nurses are expected to exercise vigilance when scrutinising prescriptions and preparing medicines, ensuring that doses are correct and appropriate for the patient. The NMC
Code requires nurses to ‘preserve safety’ and ‘practise effectively’, which includes preventing harm through careful checking and adherence to local medicines management policies.
Lack of mandatory refresher training
Registered nurses are expected to maintain up-to-date knowledge and competence in medicines management through initial training and regular refresher programmes. The NMC Code requires nurses to ‘keep your knowledge and skills up to date’ and to practise safely by recognising the limits of their competence.
The NICE medicines optimisation guidance NG 5 (2015) referenced above recommends that organisations support healthcare professionals through training and education to ensure safe prescribing, dispensing and administration. In this specific case, education and training alone would not prevent these types of safety system issues and would not be sufficient to mitigate the risk of reoccurrence. Systems improvements and mechanisms will need to be implemented to ensure lessons are learnt and that the current organisational and systems factors and processes highlighted in this case are addressed, to ensure the safe and effective checking and administration of medications. This has been substantiated by safety research and incident analysis.
The Royal College of Nursing guidance emphasises that medicines administration training should be refreshed periodically to ensure familiarity with current legislation, local policies and best practice in areas such as controlled drugs, high risk medicines, and safe prescribing. Refresher training also reinforces the importance of double checking, accurate documentation and escalation procedures when errors or adverse reactions occur.
Local Actions The Princess Alexandra Hospital NHS Trust will be providing their own response to this Report, however, the Hertfordshire & West Essex ICB have advised NHS England of the Trust’s governance arrangements and actions being taken to address the concerns raised. It is understood that the Trust’s Patient Safety Group (PSG) has active oversight of several of the areas highlighted in the Report, particularly medicines safety, recognition of deterioration, and incident learning. Medicines safety is a standing agenda item at their PSG, supported by the Medicines Optimisation Group and Medication Safety Officer, with regular review of prescribing and administration incidents, controlled drugs governance, and training compliance. The PSG has recognised gaps in training uptake and has been sighted on system- level behaviours through its routine oversight of medicines safety and incident learning. Themes PSG have been sighted on include:
• Variable engagement with medicines safety processes, such as inconsistent uptake of medicines management training and variation in adherence to medicines administration standards.
• Inconsistent escalation behaviours, for example delays in escalating concerns or delays in closing incidents and embedding learning.
• Operational pressures influencing practice, such as missed opportunities to scrutinise prescriptions or incomplete discharge processes.
• Variation in response to clinical or governance challenge, where concerns about documentation or compliance have not always been acted on promptly. PSG has strengthened leadership challenge, required divisional action plans where compliance is low, and continues to monitor medicines safety, controlled drugs governance and deterioration as standing agenda items.” Recognition and escalation of deteriorating patients is overseen through the Deteriorating Patient Group, with additional mitigation introduced via 12-hour harm reviews in urgent care settings to examine escalation, observations and clinical response. The PSG has also strengthened its focus on timely incident closure and learning, with senior leadership challenges and actions in place to ensure serious incidents are reviewed, learning is embedded, and assurance is provided through the Quality & Safety Committee and Trust Board. I would also like to provide further assurances on the national NHS England work taking place around the Reports to Prevent Future Deaths. All reports received are discussed by the Regulation 28 Working Group, comprising Regional Medical Directors, and other clinical and quality colleagues from across the regions. This ensures that key learnings and insights around events, such as the sad death of Paolino, are shared across the NHS at both a national and regional level and helps us to pay close attention to any emerging trends that may require further review and action.
Thank you for bringing these important patient safety issues to my attention and please do not hesitate to contact me should you need any further information.
Action Planned
The Princess Alexandra Hospital is reviewing this incident under its governance processes and considering additional measures, including enhanced training and monitoring. The Mandatory Learning Oversight Group is actively reviewing the training framework, including whether medicines management training should move from essential to mandatory status. (AI summary)
The Princess Alexandra Hospital is reviewing this incident under its governance processes and considering additional measures, including enhanced training and monitoring. The Mandatory Learning Oversight Group is actively reviewing the training framework, including whether medicines management training should move from essential to mandatory status. (AI summary)
View full response
Dear Coroner Hayes, REGULATION 28: REPORT TO PREVENT FUTURE DEATHS I write in the matter of the late Paolino Amico in response to your recent Regulation 28 Report to prevent future deaths which was issued on 17th November 2025. Mr Amico was admitted to Princess Alexandra Hospital on 14th May 2024 complaining of shortness of breath and productive cough. He had a medical history of metastatic urothelial carcinoma and had received experimental treatment at Barts Hospital however this had been discontinued due to disease progression. CT scan on admission identified dramatic progression of pulmonary metastatic disease since a previous CT scan in January 2024. There was no pulmonary embolism.
He was treated with oxygen, nebulisers, fluids and antibiotics. His oxygen requirements during admission were 2 litres reducing to 1litre.
Following discussion with the family a Do not resuscitate form was signed. A discussion was had with the family regarding any further treatment such as chemotherapy. The oncology consultant advised the family that Mr Amico was unable to have chemotherapy whilst on oxygen. It was discussed that attempts to wean Mr Amico off oxygen would be attempted.
Mr Amico was discharged home on 29th May 2024 with referral to the community palliative care and home oxygen. Unfortunately, he was readmitted to Princess Alexandra Hospital on 9th June 2024 with community acquired pneumonia and died on 12th June 2024.
I note the eight areas of concern which you have raised and will respond to in turn.
1. The consultant required a discharge plan for oxygen therapy to be in place before Mr Amico could go home.
The hospital discharge plan and medications were confusing and the referral for oxygen therapy requirement was unclear
PAT testing for the machine was out of date.
Paramedics advised the family that the oxygen provided on Mr Amico’s discharge was low flow and was not meeting his oxygen requirements with his oxygen saturations at 68% and this immediately improved on ambulance crew equipment.
On the 28th May 2024 Mr Amico was assessed by the respiratory Clinical nurse specialist with Mr Amico’s daughter and the following plan was agreed. He was assessed as requiring home oxygen, nebulisers, analgesia and review of the dietician when at home. At the time of assessment Mr Amico was requiring 1litre of oxygen per min via nasal cannula. His oxygen saturation level was 89%
The respiratory clinical nurse specialist completed an order form for home oxygen requesting the following:
• 2 static concentrators to provide 1litre of oxygen per min via a nasal cannula for 20-22 hours per day.
• 4 Standard ambulatory cylinders to provide 1litre of oxygen per min via nasal cannula for 1-4 hours a day
The equipment was delivered and installed to Mr Amico’s home address on 29th May 2024 by BOC gases the company who supply home oxygen, prior to his discharge.
Portable Appliance Testing (PAT) is a process used to ensure the safety of electrical appliances and equipment. The head of patient services at BOC has informed our operations team that they do not PAT test concentrators as there is no legal requirement for them to be PAT tested.
Our operations team report that the concentrator had likely been PAT tested when it had been previously provided to a care home as part of their legal requirements.
BOC have confirmed that they will ensure any stickers are removed from any concentrators being returned prior to leasing them out again and apologise for any confusion.
The discharge plan included a referral to the community respiratory team to monitor oxygen, district nursing for medication review and Specialist palliative care team
(SPCT) and to Isabel Hospice. Referral was completed on the 29th May
2024.
The comments from the paramedics relate to Mr Amico’s oxygen requirement at the time they assessed him. At the time of discharge the respiratory nurse had assessed Mr Amico and his oxygen requirements based on an evidence-based assessment and the appropriate level of oxygen based on those observations was prescribed and arranged for him at home.
2. Mr Amico did not receive his prescribed medications during his second admissions when he was readmitted to hospital on 9 June.
a. On 9 June a doctor in Accident & Emergency had reviewed Mr Amico’s prescribed medications and increased liquid oral morphine sulphate 10 mg in 5mL Solution 4 hourly as required with 2.5 -5 mg max 6 doses at 22:57 hours with slow released morphine sulphate (MST) continued 2 times daily. Trust staff did not administer any morphine to Mr Amico although he and his family were raising concerns about his high level of pain.
Mr Amico was admitted to PAHT on 9th June 2024 at 17.21and he was triaged by advanced clinical practitioner (ACP) at 18.26. At 18.50 he was reviewed by a FY2 doctor and referred to the medical team.
He was reviewed by the medical clinician at 21.33 and no account was taken that he had not received his 8pm MST dose.
On 9th June 2024 at 22.58 Morphine Sulphate (MST) modified release was prescribed for twice daily at 08.00 and 20.00. Oramorph was also prescribed as required (PRN).
b. The family was informed incorrectly that medications had not been prescribed. On the morning of 10 June, the family were given permission by a nurse to dispense from Mr Amico’s own supply of medications that he had brought to the hospital due to his level of pain. This was not accurately recorded in Mr Amico’s record. Mr Amico took his prescribed morning dose of MST.
On 9th June 2024 at 22.58 Morphine Sulphate (MST) modified release was prescribed for Mr Amico twice daily at 08.00 and 20.00. Oramorph was also prescribed PRN.
The emergency department do not have a stock of MST. At the time there was not a patients’ own controlled drug book to record controlled medication. The administration was recorded on JAC, the Trust electronic medication system that his family had given his regular prescribed medication.
As part of the learning from this incident a patients’ own controlled drug book has now been introduced in ED to ensure that this is recorded and accounted for within the department.
c. On 10 June the nurse in the emergency department did not escalate to the nurse in charge or a senior doctor that she could not locate the doctor allocated to Mr Amico and instead approached a foundation year 1 doctor to prescribe pain relief for Mr Amico. The nurse asked the doctor who was junior and very busy that the frequency of the morphine needed to be increased for Mr Amico. The doctor did not escalate the matter and did not review Mr Amico before prescribing a controlled drug.
A Multi-Disciplinary After-Action Review meeting was held, including staff involved in the incident. This identified learnings and actions to be taken. It established that the ED nurses looking after Mr Amico had been redeployed from another ward so were not fully aware of the ED escalation process that occurs in the emergency department.
As part of the learning following the after action review the escalation process with nurses redeployed from base ward to other areas need to be included as part of the orientation specific to the area they are redeployed to.
Further learning was discussed in regards to doctors: regardless of seniority, they must take responsibility when approached by nurses to review a patient. If they acknowledge the patient is not under their care and a nurse is unable to locate the appropriate doctor, they must escalate to the nurse in charge (NIC). Once a doctor has agreed to review a patient they should review the relevant background and assess the patient face to face.
The doctor who changed the prescription reviewed the incident with his educational supervisor and as part of his reflection acknowledged that he would take the responsibility to not alter any the treatment without at least reviewing the patient first.
d. Neither the nurse nor the doctor sufficiently scrutinised the medication prescribed on 9th June on the Trust system that would have shown the correct medications. This led to a prescription error being made with MST being increased from 2 times daily to 4 times daily. Mr Amico was not referred for pain management.
Mr Amico’s regular MST was modified to 4 hourly. Modifying an existing prescription bypasses the medication clinical support (MCDS) attached to EPMA (Electronic Prescribing & Medications Administration system), as well as any warnings or additional information. We have now removed the modify option to prescriptions (this was done first on our previous EPMA system, and has continued onto Cerner/AlexHealth).
What this means is that to change a prescription, a doctor would have to either click ‘cancel/reorder’ or ‘discontinue’ the drug and add a new drug to the system, both of which would force the prescriber into acknowledging any warnings and overriding any interactions picked up by the MCDS.
In addition, we have recognised there is a huge variation in morphine formulation and type and have made the naming of products clearer. For example, MST is noted as ‘Morphine MODIFIED RELEASE 12 HOURLY tablets on the system. We have also pre-defined the frequency as twice a day.
If the same prescription was to be changed today, it would bring up warnings about formulations of opioids, have the frequency predefined as twice a day, and the MCDS would flag to the prescriber that morphine sulphate oral solution is already prescribed.
This brings in an additional layer of clinical review and judgement, guiding the prescriber to select an appropriate medication. For all modified-release preparations of morphine, this list labels them as ’12 hourly preparations’ and pre-loads the frequency as twice a day.
e. Mr Amico then moved to a ward. Multiple nurses were involved in checking and administering a controlled drug morphine sulphate slow release (MST) on 5 separate occasions between 10 and 11 June 2024 and did not raise concerns about the potential for a prescription error or note that Mr Amico had already received 1 dose of MST that morning.
The Trust acknowledged that the medication administration error occurred and this was discussed with the staff involved through the following actions:
An after action review meeting took place on 26th June 2024 and included:
• Associate Director for Governance and Quality – Chair
• Doctor involved in prescribing the MST
• Acute Medicine Clinical Lead (to support doctor involved)
• Nurses involved in administration
• Matron for Medicine Division (to support nurses involved)
• Lead Professional Nurse Advocate
• Medication Safety Officer
• Patient Safety & Quality Leads – Medicine and Urgent & Emergency Care
Restorative clinical supervision took place in June 2024, which was a reflective discussion with special emphasis on how to manage challenging prescribers and how to have an effective professional discussion when in doubt of management plan, and how to escalate higher if still in doubt.
Ward Practice development team carried out a professional nurse advocate session, completed in June 2024. This included a review of controlled drugs and their frequencies, palliative care and controlled drug frequency changes, importance of clear communication and escalation when patient's Early Warning Score changes.
Monthly ongoing meetings with ward matron and chief pharmacist and EPMA lead to review all incident themes for ongoing monitoring.
Learning was shared across the Divisions and Trustwide by the Patient Safety and Quality (PSQ) Lead Nurse and discussed at Medicine Divisional Governance meeting and learning from deaths group.
3. Mr Amico’s NEWS score increased, and an emergency call was not put out on 11 June when it was established that Mr Amico was unresponsive even to pain from 03:00 hours.
The Trust acknowledges there are discrepancies with the medical records documentation around the period of the 11th June.
From the observation records and medication chart, Mr Amico’s NEWS score at
01.47 was 3, at 05.25 MST was given to Mr Amico which consists of an oral tablet being given and swallowed.
At 06.46 Mr Amico’s NEWS score increased to 10. This was escalated to hospital @night, CCOT and Nurse in charge. It was at this time the family raised concerns regards to the MST being given 4 hourly instead of Oramorph
It is noted that the documentation from the doctor who reviewed Mr Amico suggests that Mr Amico had been unresponsive since 3 am however the Trust is unable to ascertain where this information came from as the observation and medication records do not corroborate that finding.
There were no concerns raised around 03.00 am that Mr Amico was unresponsive or that his condition had deteriorated at that time. If that had been the case then his deteriorating condition would have been escalated to the OOH team.
If there had been any concerns around him being unresponsive at 05.25 when he took the further dose of MST, escalation would have occurred at that time.
4. The on-call doctor was called approximately one hour after Mr Amico’s NEWS score was found to be 10 and arrived at 07:50, this was not an emergency call. The on-call doctor had not been informed of:
a. the deterioration in Mr Amico’s presentation during the night
The hospital at night team were contacted following the raised NEWS score of 10 at
06.46 and attended immediately. The doctor was told by the family that Mr Amico had been unresponsive since 3am, however medication had been taken by Mr Amico at 05.25.
Blood gas recording was at 07.30.
b. that the family had informed nursing staff of their concerns Mr Amico had been given the wrong medication when he was noted to be unresponsive at approximately 03:00 hours, that should have immediately raised concerns about an overdose of MST.
According to the nursing records it was at 06.46 when Mr Amico was found to be drowsier when his relative asked what medication he was being given through the night and questioned why he had been receiving MST every 4 hours as he only took it twice in 24hours at home.
5. The on-call doctor escalated concerns immediately but no emergency call was put out.
An emergency call was not required at that time as all appropriate care was initiated promptly.
6. Mr Amico morphine overdose was partially treated:
a. There was an immediate response to Naloxone but the opioid reversal for overdose was not in accordance with British National Formulary guidelines or with an NHS England alert previously issued.
The prescription of Naloxone was incorrect; it was prescribed in line with acute overdoses and not for patients on long-acting chronic therapy. There is prescribing guidance in the BNF, and in the prescribing alert (first released in 2014, and rereleased in 2019). Appendix 1
The BNF highlights that doses used in acute opioid/opiate overdose may NOT be appropriate for the management of opioid/opiate induced respiratory depression and sedation in those receiving palliative care and in chronic opioid/opiate use. The recommended dose for adults in post-operative respiratory depression and for palliative care and chronic opioid/opiate use by intravenous injection is 100 to 200 micrograms (1.5 to 3 micrograms/kg). If the response is inadequate, give subsequent dose of 100 micrograms every two minutes. Even where doses are given as recommended, there is still a need for careful monitoring of vital observations and maintaining or restoring pain relief.
This has been shared by the palliative care team at educational events. The Medication Safety Officer is also liaising with the EPMA team to see how we can utilise AlexHealth to inform prescribers/safeguard against a repeat.
We have also had two ICS/PAH collaborative events around opioids for grand round (one in November 2024, another booked for February 2026).
The Trust also has a policy on Naloxone, which was reviewed following this incident. see Appendix 2.
b. There was no consideration or plan for alternative pain management in a patient who had been receiving morphine pain relief as part of his treatment plan for cancer.
c. Mr Amico suffered acute withdrawal syndrome and family complained about his suffering to hospital staff that they stated was not ameliorated. An emergency call would have triggered the attendance of an
Anaesthetist who could have given advice on opioid reversal in a palliative patient.
It is documented in the hospital records that Mr Amico was reviewed by a palliative care consultant on 11th June 2024 at 10.10am and a plan was discussed with the family regarding starting midazolam for agitation and alfentanil via a syringe driver for pain.
On 11th June 2024 at 13.00 Mr Amico was reviewed by an CT3 anaesthetist and the plan regarding the Naloxone infusion was discussed with the ITU consultant who agreed the plan. On 12th June at 03.00 Mr Amico seemed agitated and haloperidol 1mg was given followed by a further dose. Agitation subsided. Mr Amico was prescribed S/C morphine (2.5mg every 4 hours if needed) after the MST, but none was administered.
7. Multiple nurses were involved in morphine administration, and all had completed their original training outside of the UK and had undertaken a Trust medicines administration training that should have recognised the prescription of MST 4 times a day was not appropriate. Mr Amico received 6 doses of MST in less than 24 hours instead of 2.
All nurses involved in this case were internationally trained and, upon joining the Trust, undertook medicines administration training in line with NMC standards. This training is currently designated as essential within PAHT, meaning it is compulsory for staff in roles requiring it. Responsibility for completion lies with the individual and their line manager, and compliance is monitored through the Trust’s TiMS system and appraisals. The medicines administration training includes key topics such as general medicines management, insulin administration, antimicrobial resistance, and controlled drugs. It is intended to ensure safe prescribing and administration practices. Despite this, the error occurred, resulting in Mr Amico receiving six doses of MST within 24 hours instead of the prescribed two. This indicates a failure in the application of training and highlights the need for strengthened competency assurance. The Trust is reviewing this incident under its governance processes and considering additional measures, including enhanced training and monitoring, to prevent recurrence.
8. Medicines administration refresher training for nurses is not mandatory and the Trust in reviewing this case has not followed a local recommendation from senior nurses for this to be included.
Medicines administration refresher training is currently not mandatory at PAHT. Initial training is classified as essential, but refresher
courses are not systematically required or monitored. Senior nursing staff previously recommended that refresher training be included as part of ongoing competency assurance; however, this recommendation has not yet been implemented. The Mandatory Learning Oversight Group (MLOG) is actively reviewing the training framework, including whether medicines management training should move from essential to mandatory status. If adopted, this would ensure refresher training is tracked, monitored, and reported at governance level. The Trust acknowledges this gap and is considering changes to strengthen compliance and patient safety. Mandatory training is defined by NHS England as statutory (legal requirement) and NHS mandatory (NHS Core Skills Framework). This is still the responsibility of the individual and line manager to complete but is monitored and reported via PAHT governance and NHSE.
In 2023 PAHT confirmed Medical Gases training could be mandatory. Currently 2216 staff including 630 staff in Medical and Dental staff group have Medical Gases on their profiles as Mandatory training.
I hope this letter helps address the concerns raised in your Regulation 28 notice for prevention of future deaths.
Please do not hesitate to contact me if you require any further details.
He was treated with oxygen, nebulisers, fluids and antibiotics. His oxygen requirements during admission were 2 litres reducing to 1litre.
Following discussion with the family a Do not resuscitate form was signed. A discussion was had with the family regarding any further treatment such as chemotherapy. The oncology consultant advised the family that Mr Amico was unable to have chemotherapy whilst on oxygen. It was discussed that attempts to wean Mr Amico off oxygen would be attempted.
Mr Amico was discharged home on 29th May 2024 with referral to the community palliative care and home oxygen. Unfortunately, he was readmitted to Princess Alexandra Hospital on 9th June 2024 with community acquired pneumonia and died on 12th June 2024.
I note the eight areas of concern which you have raised and will respond to in turn.
1. The consultant required a discharge plan for oxygen therapy to be in place before Mr Amico could go home.
The hospital discharge plan and medications were confusing and the referral for oxygen therapy requirement was unclear
PAT testing for the machine was out of date.
Paramedics advised the family that the oxygen provided on Mr Amico’s discharge was low flow and was not meeting his oxygen requirements with his oxygen saturations at 68% and this immediately improved on ambulance crew equipment.
On the 28th May 2024 Mr Amico was assessed by the respiratory Clinical nurse specialist with Mr Amico’s daughter and the following plan was agreed. He was assessed as requiring home oxygen, nebulisers, analgesia and review of the dietician when at home. At the time of assessment Mr Amico was requiring 1litre of oxygen per min via nasal cannula. His oxygen saturation level was 89%
The respiratory clinical nurse specialist completed an order form for home oxygen requesting the following:
• 2 static concentrators to provide 1litre of oxygen per min via a nasal cannula for 20-22 hours per day.
• 4 Standard ambulatory cylinders to provide 1litre of oxygen per min via nasal cannula for 1-4 hours a day
The equipment was delivered and installed to Mr Amico’s home address on 29th May 2024 by BOC gases the company who supply home oxygen, prior to his discharge.
Portable Appliance Testing (PAT) is a process used to ensure the safety of electrical appliances and equipment. The head of patient services at BOC has informed our operations team that they do not PAT test concentrators as there is no legal requirement for them to be PAT tested.
Our operations team report that the concentrator had likely been PAT tested when it had been previously provided to a care home as part of their legal requirements.
BOC have confirmed that they will ensure any stickers are removed from any concentrators being returned prior to leasing them out again and apologise for any confusion.
The discharge plan included a referral to the community respiratory team to monitor oxygen, district nursing for medication review and Specialist palliative care team
(SPCT) and to Isabel Hospice. Referral was completed on the 29th May
2024.
The comments from the paramedics relate to Mr Amico’s oxygen requirement at the time they assessed him. At the time of discharge the respiratory nurse had assessed Mr Amico and his oxygen requirements based on an evidence-based assessment and the appropriate level of oxygen based on those observations was prescribed and arranged for him at home.
2. Mr Amico did not receive his prescribed medications during his second admissions when he was readmitted to hospital on 9 June.
a. On 9 June a doctor in Accident & Emergency had reviewed Mr Amico’s prescribed medications and increased liquid oral morphine sulphate 10 mg in 5mL Solution 4 hourly as required with 2.5 -5 mg max 6 doses at 22:57 hours with slow released morphine sulphate (MST) continued 2 times daily. Trust staff did not administer any morphine to Mr Amico although he and his family were raising concerns about his high level of pain.
Mr Amico was admitted to PAHT on 9th June 2024 at 17.21and he was triaged by advanced clinical practitioner (ACP) at 18.26. At 18.50 he was reviewed by a FY2 doctor and referred to the medical team.
He was reviewed by the medical clinician at 21.33 and no account was taken that he had not received his 8pm MST dose.
On 9th June 2024 at 22.58 Morphine Sulphate (MST) modified release was prescribed for twice daily at 08.00 and 20.00. Oramorph was also prescribed as required (PRN).
b. The family was informed incorrectly that medications had not been prescribed. On the morning of 10 June, the family were given permission by a nurse to dispense from Mr Amico’s own supply of medications that he had brought to the hospital due to his level of pain. This was not accurately recorded in Mr Amico’s record. Mr Amico took his prescribed morning dose of MST.
On 9th June 2024 at 22.58 Morphine Sulphate (MST) modified release was prescribed for Mr Amico twice daily at 08.00 and 20.00. Oramorph was also prescribed PRN.
The emergency department do not have a stock of MST. At the time there was not a patients’ own controlled drug book to record controlled medication. The administration was recorded on JAC, the Trust electronic medication system that his family had given his regular prescribed medication.
As part of the learning from this incident a patients’ own controlled drug book has now been introduced in ED to ensure that this is recorded and accounted for within the department.
c. On 10 June the nurse in the emergency department did not escalate to the nurse in charge or a senior doctor that she could not locate the doctor allocated to Mr Amico and instead approached a foundation year 1 doctor to prescribe pain relief for Mr Amico. The nurse asked the doctor who was junior and very busy that the frequency of the morphine needed to be increased for Mr Amico. The doctor did not escalate the matter and did not review Mr Amico before prescribing a controlled drug.
A Multi-Disciplinary After-Action Review meeting was held, including staff involved in the incident. This identified learnings and actions to be taken. It established that the ED nurses looking after Mr Amico had been redeployed from another ward so were not fully aware of the ED escalation process that occurs in the emergency department.
As part of the learning following the after action review the escalation process with nurses redeployed from base ward to other areas need to be included as part of the orientation specific to the area they are redeployed to.
Further learning was discussed in regards to doctors: regardless of seniority, they must take responsibility when approached by nurses to review a patient. If they acknowledge the patient is not under their care and a nurse is unable to locate the appropriate doctor, they must escalate to the nurse in charge (NIC). Once a doctor has agreed to review a patient they should review the relevant background and assess the patient face to face.
The doctor who changed the prescription reviewed the incident with his educational supervisor and as part of his reflection acknowledged that he would take the responsibility to not alter any the treatment without at least reviewing the patient first.
d. Neither the nurse nor the doctor sufficiently scrutinised the medication prescribed on 9th June on the Trust system that would have shown the correct medications. This led to a prescription error being made with MST being increased from 2 times daily to 4 times daily. Mr Amico was not referred for pain management.
Mr Amico’s regular MST was modified to 4 hourly. Modifying an existing prescription bypasses the medication clinical support (MCDS) attached to EPMA (Electronic Prescribing & Medications Administration system), as well as any warnings or additional information. We have now removed the modify option to prescriptions (this was done first on our previous EPMA system, and has continued onto Cerner/AlexHealth).
What this means is that to change a prescription, a doctor would have to either click ‘cancel/reorder’ or ‘discontinue’ the drug and add a new drug to the system, both of which would force the prescriber into acknowledging any warnings and overriding any interactions picked up by the MCDS.
In addition, we have recognised there is a huge variation in morphine formulation and type and have made the naming of products clearer. For example, MST is noted as ‘Morphine MODIFIED RELEASE 12 HOURLY tablets on the system. We have also pre-defined the frequency as twice a day.
If the same prescription was to be changed today, it would bring up warnings about formulations of opioids, have the frequency predefined as twice a day, and the MCDS would flag to the prescriber that morphine sulphate oral solution is already prescribed.
This brings in an additional layer of clinical review and judgement, guiding the prescriber to select an appropriate medication. For all modified-release preparations of morphine, this list labels them as ’12 hourly preparations’ and pre-loads the frequency as twice a day.
e. Mr Amico then moved to a ward. Multiple nurses were involved in checking and administering a controlled drug morphine sulphate slow release (MST) on 5 separate occasions between 10 and 11 June 2024 and did not raise concerns about the potential for a prescription error or note that Mr Amico had already received 1 dose of MST that morning.
The Trust acknowledged that the medication administration error occurred and this was discussed with the staff involved through the following actions:
An after action review meeting took place on 26th June 2024 and included:
• Associate Director for Governance and Quality – Chair
• Doctor involved in prescribing the MST
• Acute Medicine Clinical Lead (to support doctor involved)
• Nurses involved in administration
• Matron for Medicine Division (to support nurses involved)
• Lead Professional Nurse Advocate
• Medication Safety Officer
• Patient Safety & Quality Leads – Medicine and Urgent & Emergency Care
Restorative clinical supervision took place in June 2024, which was a reflective discussion with special emphasis on how to manage challenging prescribers and how to have an effective professional discussion when in doubt of management plan, and how to escalate higher if still in doubt.
Ward Practice development team carried out a professional nurse advocate session, completed in June 2024. This included a review of controlled drugs and their frequencies, palliative care and controlled drug frequency changes, importance of clear communication and escalation when patient's Early Warning Score changes.
Monthly ongoing meetings with ward matron and chief pharmacist and EPMA lead to review all incident themes for ongoing monitoring.
Learning was shared across the Divisions and Trustwide by the Patient Safety and Quality (PSQ) Lead Nurse and discussed at Medicine Divisional Governance meeting and learning from deaths group.
3. Mr Amico’s NEWS score increased, and an emergency call was not put out on 11 June when it was established that Mr Amico was unresponsive even to pain from 03:00 hours.
The Trust acknowledges there are discrepancies with the medical records documentation around the period of the 11th June.
From the observation records and medication chart, Mr Amico’s NEWS score at
01.47 was 3, at 05.25 MST was given to Mr Amico which consists of an oral tablet being given and swallowed.
At 06.46 Mr Amico’s NEWS score increased to 10. This was escalated to hospital @night, CCOT and Nurse in charge. It was at this time the family raised concerns regards to the MST being given 4 hourly instead of Oramorph
It is noted that the documentation from the doctor who reviewed Mr Amico suggests that Mr Amico had been unresponsive since 3 am however the Trust is unable to ascertain where this information came from as the observation and medication records do not corroborate that finding.
There were no concerns raised around 03.00 am that Mr Amico was unresponsive or that his condition had deteriorated at that time. If that had been the case then his deteriorating condition would have been escalated to the OOH team.
If there had been any concerns around him being unresponsive at 05.25 when he took the further dose of MST, escalation would have occurred at that time.
4. The on-call doctor was called approximately one hour after Mr Amico’s NEWS score was found to be 10 and arrived at 07:50, this was not an emergency call. The on-call doctor had not been informed of:
a. the deterioration in Mr Amico’s presentation during the night
The hospital at night team were contacted following the raised NEWS score of 10 at
06.46 and attended immediately. The doctor was told by the family that Mr Amico had been unresponsive since 3am, however medication had been taken by Mr Amico at 05.25.
Blood gas recording was at 07.30.
b. that the family had informed nursing staff of their concerns Mr Amico had been given the wrong medication when he was noted to be unresponsive at approximately 03:00 hours, that should have immediately raised concerns about an overdose of MST.
According to the nursing records it was at 06.46 when Mr Amico was found to be drowsier when his relative asked what medication he was being given through the night and questioned why he had been receiving MST every 4 hours as he only took it twice in 24hours at home.
5. The on-call doctor escalated concerns immediately but no emergency call was put out.
An emergency call was not required at that time as all appropriate care was initiated promptly.
6. Mr Amico morphine overdose was partially treated:
a. There was an immediate response to Naloxone but the opioid reversal for overdose was not in accordance with British National Formulary guidelines or with an NHS England alert previously issued.
The prescription of Naloxone was incorrect; it was prescribed in line with acute overdoses and not for patients on long-acting chronic therapy. There is prescribing guidance in the BNF, and in the prescribing alert (first released in 2014, and rereleased in 2019). Appendix 1
The BNF highlights that doses used in acute opioid/opiate overdose may NOT be appropriate for the management of opioid/opiate induced respiratory depression and sedation in those receiving palliative care and in chronic opioid/opiate use. The recommended dose for adults in post-operative respiratory depression and for palliative care and chronic opioid/opiate use by intravenous injection is 100 to 200 micrograms (1.5 to 3 micrograms/kg). If the response is inadequate, give subsequent dose of 100 micrograms every two minutes. Even where doses are given as recommended, there is still a need for careful monitoring of vital observations and maintaining or restoring pain relief.
This has been shared by the palliative care team at educational events. The Medication Safety Officer is also liaising with the EPMA team to see how we can utilise AlexHealth to inform prescribers/safeguard against a repeat.
We have also had two ICS/PAH collaborative events around opioids for grand round (one in November 2024, another booked for February 2026).
The Trust also has a policy on Naloxone, which was reviewed following this incident. see Appendix 2.
b. There was no consideration or plan for alternative pain management in a patient who had been receiving morphine pain relief as part of his treatment plan for cancer.
c. Mr Amico suffered acute withdrawal syndrome and family complained about his suffering to hospital staff that they stated was not ameliorated. An emergency call would have triggered the attendance of an
Anaesthetist who could have given advice on opioid reversal in a palliative patient.
It is documented in the hospital records that Mr Amico was reviewed by a palliative care consultant on 11th June 2024 at 10.10am and a plan was discussed with the family regarding starting midazolam for agitation and alfentanil via a syringe driver for pain.
On 11th June 2024 at 13.00 Mr Amico was reviewed by an CT3 anaesthetist and the plan regarding the Naloxone infusion was discussed with the ITU consultant who agreed the plan. On 12th June at 03.00 Mr Amico seemed agitated and haloperidol 1mg was given followed by a further dose. Agitation subsided. Mr Amico was prescribed S/C morphine (2.5mg every 4 hours if needed) after the MST, but none was administered.
7. Multiple nurses were involved in morphine administration, and all had completed their original training outside of the UK and had undertaken a Trust medicines administration training that should have recognised the prescription of MST 4 times a day was not appropriate. Mr Amico received 6 doses of MST in less than 24 hours instead of 2.
All nurses involved in this case were internationally trained and, upon joining the Trust, undertook medicines administration training in line with NMC standards. This training is currently designated as essential within PAHT, meaning it is compulsory for staff in roles requiring it. Responsibility for completion lies with the individual and their line manager, and compliance is monitored through the Trust’s TiMS system and appraisals. The medicines administration training includes key topics such as general medicines management, insulin administration, antimicrobial resistance, and controlled drugs. It is intended to ensure safe prescribing and administration practices. Despite this, the error occurred, resulting in Mr Amico receiving six doses of MST within 24 hours instead of the prescribed two. This indicates a failure in the application of training and highlights the need for strengthened competency assurance. The Trust is reviewing this incident under its governance processes and considering additional measures, including enhanced training and monitoring, to prevent recurrence.
8. Medicines administration refresher training for nurses is not mandatory and the Trust in reviewing this case has not followed a local recommendation from senior nurses for this to be included.
Medicines administration refresher training is currently not mandatory at PAHT. Initial training is classified as essential, but refresher
courses are not systematically required or monitored. Senior nursing staff previously recommended that refresher training be included as part of ongoing competency assurance; however, this recommendation has not yet been implemented. The Mandatory Learning Oversight Group (MLOG) is actively reviewing the training framework, including whether medicines management training should move from essential to mandatory status. If adopted, this would ensure refresher training is tracked, monitored, and reported at governance level. The Trust acknowledges this gap and is considering changes to strengthen compliance and patient safety. Mandatory training is defined by NHS England as statutory (legal requirement) and NHS mandatory (NHS Core Skills Framework). This is still the responsibility of the individual and line manager to complete but is monitored and reported via PAHT governance and NHSE.
In 2023 PAHT confirmed Medical Gases training could be mandatory. Currently 2216 staff including 630 staff in Medical and Dental staff group have Medical Gases on their profiles as Mandatory training.
I hope this letter helps address the concerns raised in your Regulation 28 notice for prevention of future deaths.
Please do not hesitate to contact me if you require any further details.
Sent To
- NHS England
- Princess Aleandra Hospital
Response Status
Linked responses
2 of 2
56-Day Deadline
12 Jan 2026
All responses received
About PFD responses
Organisations named in PFD reports must respond within 56 days explaining what actions they are taking.
Source: Courts and Tribunals Judiciary
Report Sections
Investigation and Inquest
On 18 June 2024 an investigation was commenced into the death of Paolino AMICO, aged 63 years. The investigation concluded at the inquest on 3 November 2025. The conclusion of the inquest was a Narrative: Mr Amico’s death from Metastatic Bladder Cancer was hastened and contributed to by multiple morphine overdoses between 10 and 11 June 2024 due to a prescription error that was not scutnised. Morphine reversal and subsequent pain relief was not managed according to the guidelines and Mr Amico suffered acute withdrawal syndrome.
Medical cause of death of ‘1a Type 2 Respiratory Failure 1b Community Acquired Pneumonia, Inadvertent Morphine Overdoses and acute withdrawal syndrome 1c Metastatic Bladder Cancer with Advanced Clinical Frailty
Medical cause of death of ‘1a Type 2 Respiratory Failure 1b Community Acquired Pneumonia, Inadvertent Morphine Overdoses and acute withdrawal syndrome 1c Metastatic Bladder Cancer with Advanced Clinical Frailty
Circumstances of the Death
Paolino Amico had a history of metastatic bladder cancer that had not responded to treatment on a clinical trial. Mr Amico was discharged from hospital on 29 May 2024 and was oxygen dependent. Mr Amico developed severe bilateral pneumonia and was admitted into Princess Alexandra Hospital on 9 June 2024 and treated with antibiotics , nebulisers and fluids. Mr Amico was not seen in person by a doctor who altered his prescription in the emergency department on 10 June. On the afternoon of 10 June Mr Amico’s medication chart was not scrutinised when he had a medical review as he was deteriorating. Due to a prescription error Mr Amico received multiple overdoses of a controlled drug morphine sulphate (slow release) on 10 and 11 June 2024 resulting in morphine accumulation that was partially reversed with naloxone on 11 June. Mr Amico was not deemed suitable for admission to intensive care for Naloxone infusion. Mr Amico died on 12 June 2024 at Princess Alexandra Hospital as a consequence of Type 2 Respiratory Failure due to Community Acquired Pneumonia and Inadvertent Morphine Overdoses with Metastatic Bladder Cancer with Advanced Clinical Frailty.There was a delay in raising a medical emergency when Mr Amico had elevated NEWS score of 10 and his morphine reversal and pain relief was not managed according to the guidelines and he suffered acute withdrawal syndrome.
Copies Sent To
Care Quality Commission
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Data sourced from Courts and Tribunals Judiciary under the Open Government Licence.