Brian Beer
PFD Report
All Responded
Ref: 2024-0564
All 1 response received
· Deadline: 16 Dec 2024
Coroner's Concerns (AI summary)
NICE guidelines on post-hip fracture anti-coagulation may be outdated, potentially increasing the risk of arterial clots due to hypercoagulability after stopping VTE prophylaxis in elderly, immobile patients.
View full coroner's concerns
If NICE guidelines as to prophylactic anti-coagulation after surgery on a hip fracture do not reflect the most up-to-date international learning, then there is a risk of future deaths being contributed to by hospitals following NICE guidelines when a longer period of anti-coagulation post-surgery would better protect them against recognised complications of the surgery. Explanation: On referral of the case to the Coroner's Court: , Medical Examiner, wrote: "Given that he had no history of atrial fibrillation, ischaemic heart disease, peripheral vascular disease or diabetes and atherosclerosis was not noted on the CT scan, there appears to be a temporal relationship between the discontinuation of the Tinzaparin and the superior mesenteric arterial thrombus causing the ischaemic bowel. Local policy was followed. Internationally the policy is evolving ... patients have longer on an anticoagulant after fractured neck of femur. Referral in light of a potential indirect link between the discontinuation of the anticoagulation and the death." In further communication with the Court in the course of the investigation, wrote: "His death is directly related to the thrombus within the superior mesenteric artery and his only other co-morbidity is advanced dementia and frailty. It is likely that if recommendations for fracture neck of femur is brought into line with the recommendations for elective hip replacement surgery, he would not have had this thrombus. Therefore, to the best of my knowledge, the cessation of the anti-coagulation did make a material difference to his death." The findings and conclusion of the Inquest were based on this evidence. After the conclusion of the Inquest, I received further communication from . In that further clarification, she stated that "venous thromboprophylaxis ('VTE') prophylaxis ... was for the prevention of venous thrombosis and this gentleman died of an arterial thrombus, therefore it is not clear what role the VTE prophylaxis plays in this, however there is potentially a state of hypercoagulability following discontinuation of VTE prophylaxis." went on to add that "our local guidelines are in line with NICE guidelines"; but she queried "whether the NICE guidelines (now 5 years old) need to acknowledge this potential risk of hypercoagulability in the immobile, elderly patients on discontinuation of the VTE prophylaxis and/or consideration of alternative agents or regimes in this particular demographic, should it become evident that there is indeed this risk." After the conclusion of the Inquest, I was also provided with an opinion from , an expert haematologist. advised that the guidance relating to venous thrombosis is not relevant to an arterial clot - and prophylaxis is not given against arterial clots. In her view, and that of two other expert practitioners in this area, the cessation of VTE prophylaxis and the development of the arterial clot were not related. added that neither she, nor her two colleagues, are aware of an evolving international consensus over the length of time for prophylaxis after a fractured neck of femur. A communication was also then received from , who added: "The Hip fracture team are aware of some emerging early evidence regarding extending VTE prophylaxis in such patients beyond the 4 week point." Bearing in mind ' evidence regarding evolving international policy, and 's indication of "some emerging early evidence" in this regard, in my opinion it is appropriate to ensure that this concern is brought to the attention of NICE, to ensure that appropriate consideration be given as to whether the national guidelines in this area require revision, particularly bearing in mind that surgery on hip fractures is far from uncommon in immobile and elderly, and therefore vulnerable, patients.
Responses
Noted
NICE acknowledges the coroner's concerns regarding arterial thrombus but clarifies that existing guidance focuses on venous thromboembolism and does not cover arterial prophylaxis. NICE will continue to monitor new evidence in this area. (AI summary)
NICE acknowledges the coroner's concerns regarding arterial thrombus but clarifies that existing guidance focuses on venous thromboembolism and does not cover arterial prophylaxis. NICE will continue to monitor new evidence in this area. (AI summary)
View full response
Dear Mr Taheri,
I write in response to your regulation 28 report, dated 21 October 2024, regarding the sad death of Mr Brian Beer. I would like to express my sincere condolences to Mr Beer’s family. Following receipt of your report, senior clinical advisers within our patient safety team have reviewed the concerns raised. We note the comment in the report that Mr Beer died of an arterial thrombus. While we have published guidance on venous thromboembolism [NG89] which covers assessing and reducing the risk of (VTE or blood clots, including deep vein thrombosis and pulmonary embolism) in people aged 16 and over in hospital, the guidance does not cover arterial prophylaxis. NG89 gives recommendations for anti-coagulation following fragility fractures of the pelvis, hip and proximal femur (1.11.2-4) and following Elective hip replacement (1.11.5-7). These state that people should be offered VTE prophylaxis for a month if the risk of VTE outweighs the risk of bleeding. The guideline also states the clinicians should ‘Balance the person's individual risk of VTE against their risk of bleeding when deciding whether to offer pharmacological thromboprophylaxis to medical patients’ (1.1.6). The decision whether to continue or discontinue anti-coagulation would be a matter for clinical judgement based on careful assessment of an individual patient and their progress after surgery. In line with the expert haematologist and her colleagues, we are not aware of evolving international consensus over the length of time for prophylaxis after a fractured neck of femur and the possibility of mesenteric thrombosis. NICE will continue to monitor new
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evidence in this area of practice. Any new evidence of sufficient quality will be considered as part of a surveillance review, as described in our guidelines manual. Your report has been shared with the surveillance team who will carry out this work. Please do let me know if you require any further information and again, I offer my sincerest condolences to Mr Beer’s family.
I write in response to your regulation 28 report, dated 21 October 2024, regarding the sad death of Mr Brian Beer. I would like to express my sincere condolences to Mr Beer’s family. Following receipt of your report, senior clinical advisers within our patient safety team have reviewed the concerns raised. We note the comment in the report that Mr Beer died of an arterial thrombus. While we have published guidance on venous thromboembolism [NG89] which covers assessing and reducing the risk of (VTE or blood clots, including deep vein thrombosis and pulmonary embolism) in people aged 16 and over in hospital, the guidance does not cover arterial prophylaxis. NG89 gives recommendations for anti-coagulation following fragility fractures of the pelvis, hip and proximal femur (1.11.2-4) and following Elective hip replacement (1.11.5-7). These state that people should be offered VTE prophylaxis for a month if the risk of VTE outweighs the risk of bleeding. The guideline also states the clinicians should ‘Balance the person's individual risk of VTE against their risk of bleeding when deciding whether to offer pharmacological thromboprophylaxis to medical patients’ (1.1.6). The decision whether to continue or discontinue anti-coagulation would be a matter for clinical judgement based on careful assessment of an individual patient and their progress after surgery. In line with the expert haematologist and her colleagues, we are not aware of evolving international consensus over the length of time for prophylaxis after a fractured neck of femur and the possibility of mesenteric thrombosis. NICE will continue to monitor new
Page | 2
evidence in this area of practice. Any new evidence of sufficient quality will be considered as part of a surveillance review, as described in our guidelines manual. Your report has been shared with the surveillance team who will carry out this work. Please do let me know if you require any further information and again, I offer my sincerest condolences to Mr Beer’s family.
Sent To
- National Institute of Health and Care Excellence
Response Status
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56-Day Deadline
16 Dec 2024
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Source: Courts and Tribunals Judiciary
Report Sections
Investigation and Inquest
On 13 March 2024 I commenced an investigation into the death of Brian BEER aged 86. The investigation concluded at the end of the inquest on 06 September 2024. The conclusion of the inquest was that: Narrative Conclusion - Brian Beer, an 86 year old gentleman, died due to a recognised complication of necessary surgery on a fractured hip sustained in an unwitnessed fall. The development of this complication was contributed to by the fact that local guidelines were followed as to the cessation of prophylactic anti-coagulants after surgery, whereas evolving international policy indicates that prophylaxis should be continued for a longer time period. The death was also contributed to by frailty and advanced dementia, which both contributed to the fall and compromised Mr Beer’s physiological reserve, such that his capacity to recover from fracture, surgery and serious illness was compromised. The medical cause of death was confirmed as: 1a Small Bowel Ischaemia 1b Superior Mesenteric Artery Thrombus 1c Advanced Dementia, Left Hip Hemiarthroplasty 08.01.24 with VTE Prophylaxis for 28 Days
Circumstances of the Death
Brian Beer died peacefully at the West Suffolk Hospital on 1 March 2024. He died of small bowel ischaemia, suffered due to a blood clot in an artery that provides blood to the small bowel. Sustaining such a blood clot is a recognised complication of surgery on a hip fracture. Mr Beer underwent a left femur head replacement on 8 January 2024, owing to a hip fracture. This fracture was sustained in an unwitnessed fall at his care home, which was contributed to by advanced dementia and frailty. Although Mr Beer received prophylactic anti-coagulation after the hip surgery, in accordance with and for the duration required by local hospital guidelines, the international policy in this regard is evolving such that patients may be given anti-coagulation after surgery for a longer period of time. The cessation of anti-coagulation in Mr Beer’s case at the time it was ceased contributed to his death.
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Data sourced from Courts and Tribunals Judiciary under the Open Government Licence.