Yusuf Seyit

PFD Report All Responded Ref: 2021-0111
Date of Report 16 April 2021
Coroner Andrew Harris
Response Deadline est. 11 June 2021
All 1 response received · Deadline: 11 Jun 2021
Coroner's Concerns (AI summary)
A high-risk patient with infection symptoms did not receive timely antibiotic intervention. There was no clear treatment plan, and the actual administration time for a critical antibiotic was not confirmed.
View full coroner's concerns
1. He was known to be at high risk of fatal infection and had developed symptoms 2 days before death and definitive proof of infection by the late afternoon of 2nd July, but it was not clear whether there was a plan for antibiotic intervention and no treatment was begun that day.

2. When in septic shock in the early hours of 3rd, three antibiotics were prescribed and our initial death report indicated treatment had begun before he died. But the medical records available to the inquest did not confirm when Amikacin was actually administered. Evidence of a consultant physician was that it needed to be within an hour.
Responses
Lewisham and Greenwich NHS Trust NHS / Health Body
10 Jun 2021
Action Taken
University Hospital Lewisham has re-audited sepsis performance against the Sepsis 6 Bundle standards, ensured all wards are stocked with the paper version of the Sepsis Assessment Bundle, reminded staff to administer critical medications within one hour of prescription, and is prioritising the implementation of an electronic (iCare) Sepsis Bundle. (AI summary)
View full response
Dear Dr Harris REGULATION 28 REPORT TO PREVENT FUTURE DEATHS Re: Mr YUSUF SEYIT am writing in response to your report dated 16 April 2021, concerning the care provided to Mr Seyit Your report highlighted two matters of concerns which are listed below_ Mr Seyit was known to be at high risk of fatal infection and had developed symotoms two days before death and definitive of infection by the late afternoon of 2020, but it was not clear whether there was plan for antibiotic intervention and no treatment was commenced that day. 2 When in septic shock in the early hours of 3rd July 2020, three antibiotics were prescribed , and the Trust initial death report indicated treatment had commenced before he died. However; the medical records available to the inquest did not confirm when Amikacin was actually administered. Evidence provided by consultant physician confirmed that it needed to be within an hour: As a result; the Trust is required to ensure the appropriate antibiotics for septic shock are prescribed and administered within the hour at all times irrespective of the time of day: Following receipt of this report; the Trust completed an internal review of the incident and confirmed that Mr Seyit was prescribed antibiotics at 07:OOhrs, which were administered at
07.49hrs which was within the hour: We acknowledge and apologise that The Trust did not provide the appropriate evidence required during the inquest High quality care for patient every day Nx: 2nd July proof every

However; the Trust has taken the opportunity to review its current practices around sepsis and take the following steps: The Trust and Division have re-audited sepsis performance on all clinical wards against the Sepsis 6 Bundle Standards and actions have been taken to improve gaps in practice This will be monitored through our internal governance processes. 2 The Trust will ensure that all wards are adequately stocked with the paper version of the Sepsis Assessment Bundle_ and all clinical staff have been reminded that prescribed critical medications are to be administered to patients within an hour of being prescribed by a doctor. This is discussed at Ward Safety huddles and local team meetings_ 3, The Trust is prioritising the implementation of an electronic (iCare) Sepsis Bundle. This was originally scheduled for 2022 Discussion have taken place with the Trust IT department and there are plans for this to be completed later this year: This will be monitored via Divisional Governance processes and assurance given via the Trust Quality and Safety Committee _ would like to assure you that the Trust has taken the concerns raised seriously and learning from this incident has been shared at the Trust Mortality Review Committee, Divisional Mortality and Morbidity and the Junior Doctors review meetings_ Should you have any further questions regarding any of the information provided in this letter or require any furtherinformation please do not hesitate to contact me_
Sent To
  • University Hospital Lewisham
Response Status
Linked responses 1 of 1
56-Day Deadline 11 Jun 2021
All responses received
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Organisations named in PFD reports must respond within 56 days explaining what actions they are taking.

Source: Courts and Tribunals Judiciary

Report Sections
Investigation and Inquest
I opened an inquest into the death of Mr Yusuf Seyit, ( and ), who died on 3rd July 2019 aged 72 years on 12th September 2019. The delay in holding the inquest was ascribed to the impact of the Covid pandemic.

The medical cause of death was: 1a Septicaemia 1b Urinary Tract Infection II Immunoglobulin G4 disease, Myelodysplastic syndrome, Diabetes Mellitus. The narrative conclusion was natural causes was contributed to by a delay in administering antibiotics in septic shock.
Circumstances of the Death
Mr Seyit suffered from multiple diseases which immunosuppressed his response to infection and had been in hospital since January. The family reported pain on passing urine on 30th June. He had an indwelling catheter and a urine infection was suspected on 1st July, when he had suprapubic tenderness as well as signs suggestive of a chest infection. The urine result was reported at 17.50 on 2nd July as highly resistant E coli, sensitive to Amikacin. At this time he was stable but there was an indicator of infection – the slightly elevated CRP of 23. He acutely deteriorated at 05.00 with septic shock and a medical review concluded at 06.25. He was prescribed three antibiotics (he had a chest infection as well) including Amikacin. It is not known when in the morning Amikacin was administered. He died at 20.00
Action Should Be Taken
The coroner draws attention of The Trust, with the family’s support, to the need to ensure that appropriate antibiotics for septic shock are available within the hour after prescription at any time of day or night. It may be that this facility is in operation but the evidence not adduced. In any event the Trust may wish to assure the public of the processes of securing administration of life-saving medication for sepsis at all times.
Related Inquiry Recommendations

Public inquiry recommendations addressing similar themes

Hepatologist Oversight and Fibroscan Access
Infected Blood Inquiry
Delayed Recognition of Deterioration
Specialist Hepatology Centre Access
Infected Blood Inquiry
Delayed Recognition of Deterioration
Uncertainty About Fibrosis
Infected Blood Inquiry
Delayed Recognition of Deterioration
Fibroscan for Liver Imaging
Infected Blood Inquiry
Delayed Recognition of Deterioration
Consultant Hepatologist Access
Infected Blood Inquiry
Delayed Recognition of Deterioration
Commissioning Hepatology Services
Infected Blood Inquiry
Delayed Recognition of Deterioration
Medicines administration
Mid Staffs Inquiry
Unsafe medication management

Data sourced from Courts and Tribunals Judiciary under the Open Government Licence.