KennethDaly
PFD Report
Partially Responded
Ref: 2019-0348
Coroner's Concerns (AI summary)
Unclear advice from consultants regarding co-prescribing multiple opioids and a lack of tailored written guidance for patients on the risks of combined opioid use were identified.
View full coroner's concerns
1) In oral evidence, the Consultant stated that no other opioids were to be taken once Morphine Sulphate and Co-Codamol had been prescribed but that prescribing of Pregabalin could continue. She set out her advice in a letter to Mr Daly’s GP dated 11 July 2018. The letter clearly stated that Fentanyl and Tapentadol should be stopped and Morphine sulphate (MST) 60mg started. The advice regarding the prescribing of pain relieving medications other than Fentanyl and Tapentadol is less clear. In relation to Dihydrocodeine and Tramadol it is stated that “He can continue using the Dihydrocodeine and very rarely Tramadol until he sees you for his next prescription. Together with the MST, I would recommend to allow him Co-Codamol 30/500mg 2 tablets up to four times a day…”. Following receipt of the letter, Tramadol and Dihydrocodeine continued to be issued by the GP practice albeit at lower quantities than previously prescribed. The GP did not seek any further guidance regarding the advice given in the letter of 11 July 2018 from the Consultant.
2) Mr Daly was a patient that was known to adjust his pain medication without seeking guidance from his GP. Whilst Mr Daly was copied in to the letter sent to his GP on 11 July 2018, he was not given any written guidance regarding his pain relief and the use of other medications (such as benzodiazepines) that was tailored to his needs as a patient.
Specifically, he was not given any written advice regarding the risks of using multiple opioid medications in combination.
2) Mr Daly was a patient that was known to adjust his pain medication without seeking guidance from his GP. Whilst Mr Daly was copied in to the letter sent to his GP on 11 July 2018, he was not given any written guidance regarding his pain relief and the use of other medications (such as benzodiazepines) that was tailored to his needs as a patient.
Specifically, he was not given any written advice regarding the risks of using multiple opioid medications in combination.
Responses
Disputed
(AI summary)
(AI summary)
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Dear Sirs Re Death of John Eric Graham (MT) This response is prepared in order to comply with the Notice of HM Coroner pursuant to Regulation 28 of the Coroners (Investigations) Regulations 2013 Regulations") At the inquest of Mr Graham, the Assistant Coroner expressed concern that carbon monoxide detectors are not routinely installed in residential accommodation rented by Rochdale Boroughwide Housing Ltd which; if not remedied, creates a risk of future deaths_ Response The Smoke and Carbon Monoxide Alarm (England) Regulations 2015 only require private landlords to install carbon monoxide detectors and Registered Providers are specifically excluded from the regulations. Further; the installation will only take place if there are rooms containing solid fuel burning appliances and such detectors are not required when there are only gas burning appliances installed This is re-iterated by the Building Regulations, Part J, which requires that when a new or replacement solid fuel appliance is installed carbon monoxide detector is fitted. However; no mention is made of gas appliances_ On the 30th April 2018 the Government announced a review into the rules that require carbon monoxide alarms to be fitted in homes across England. The review is considering whether there should be blanket requirement to install alarms for all methods of heating, including gas and oil appliances. Until the utcome of that review is known it would not be prudent to consider a wholesale installation programme in the absence the detailed requirements that such recommendation would bring: For example, the most recent changes in Scotland will require smoke and carbon monoxide detectors in specific locations and of specific types. They will also need to be hard wired when those regulations come into force in Scotland in February GET | 202UUH Follow rbhousing: Visit us at rbh.org uk or talk to US on Yopu Tube] 0800 027 7769 or (01706) 274100 Rochdale Boroughwide Housing Limited is charitable community benefit society: FCA register number 31452 R. Registered Office: Sandbrook |louse, Sandbrook Rochdale OLII IRY. Registered as provider of social housing RSH Register nurber 4607. Way ("The Way;
Rochdale Boroughwide Housing will continue to monitor the outcome of the current review and any recommendations which follow will be considered for implementation.
Rochdale Boroughwide Housing will continue to monitor the outcome of the current review and any recommendations which follow will be considered for implementation.
Sent To
- Bart’s Health NHS Trust
Response Status
Linked responses
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56-Day Deadline
12 Jan 2020
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Source: Courts and Tribunals Judiciary
Report Sections
Investigation and Inquest
On 10 December 2018, Senior Coroner Mary Hassell commenced an investigation into the death of Kenneth John Daly aged 51 years. The investigation concluded at the end of the inquest which was conducted by me on 3 October 2019.
The conclusion of the inquest was that Mr Daly’s death was drug related.
The medical cause of death was: 1a multi-drug toxicity (Morphine, Dihydrocodeine, Codeine)
My short form conclusion was that: “Mr Daly had longstanding problems with chronic back pain and anxiety. He was prescribed multiple medications for this. Following review by pain management specialists, it was decided that Mr Daly’s opioid medications would be reduced to Morphine and Co-Codamol. However, he continued to be issued with Dihydrocodeine prescriptions. Mr Daly overdosed on Morphine, Dihydrocodeine and Codeine which was taken alongside prescribed Pregabalin and benzodiazepine medication. Mr Daly was found deceased at his home on 4 December 2018.”
The conclusion of the inquest was that Mr Daly’s death was drug related.
The medical cause of death was: 1a multi-drug toxicity (Morphine, Dihydrocodeine, Codeine)
My short form conclusion was that: “Mr Daly had longstanding problems with chronic back pain and anxiety. He was prescribed multiple medications for this. Following review by pain management specialists, it was decided that Mr Daly’s opioid medications would be reduced to Morphine and Co-Codamol. However, he continued to be issued with Dihydrocodeine prescriptions. Mr Daly overdosed on Morphine, Dihydrocodeine and Codeine which was taken alongside prescribed Pregabalin and benzodiazepine medication. Mr Daly was found deceased at his home on 4 December 2018.”
Circumstances of the Death
Kenneth Daly had problems with chronic pain in his lower back and legs following an accident in 2000. He also had peripheral neuropathy, degenerative disc disease, coronary artery disease and anxiety. Pain had a substantial impact on Mr Daly’s quality of life and affected his ability to undertake activities of daily living.
Mr Daly had been using Fentanyl patches (100 mcg/hour) for pain relief. He wanted to stop using Fentanyl because of its impact on his quality of life and memory. His GP had reduced the dosage to 75 mcg/hour. Mr Daly then noted that his physical function had deteriorated. Mr Daly was also prescribed Dihydrocodeine, Amitriptyline, Pregabalin and Tramadol for pain relief and Venlafaxine, Olanzapine, Diazepam and Temazepam for his mental health. Mr Daly was known to change the amounts of medication that he took depending on how he felt at particular times. His GP decided to refer Mr Daly to pain management specialists in 2017 for guidance on pain management with a particular intention of reducing the use of opioid medications.
In January 2018, the Consultant in Anaesthesia and Pain Management initially recommended reducing Fentanyl further to 50 mcg/hour and additionally prescribing Tapentadol. He was also referred for physiotherapy. Mr Daly did not find the changes to medication helpful and continued to use Dihydrocodeine and Tramadol. In July 2018, Mr Daly attended a further appointment with his Consultant at the medication management clinic. It was noted that he reported high levels of pain, anxiety and depression and low levels of health related quality of life. It was decided to stop Fentanyl altogether and start Morphine Sulphate MR 60mg twice per day with Co-Codamol 30/500mg for breakthrough pain. The pain management specialist’s view was that no other opioids were to be taken once Morphine Sulphate and Co-Codamol had been prescribed but that prescribing of Pregabalin could continue.
Mr Daly’s GP continue to issue prescriptions for Dihydrocodeine and Tramadol at reduced quantities from the amounts issued in the past. In the later part of
2018, his GP also referred him to see specialists as he reported having a number of falls. The cause of the falls had not been identified at the time of Mr Daly’s death.
On 4 December 2018, Mr Daly was found dead at his home. Toxicology analysis found Morphine, Dihydrocodeine, Codeine, Pregabalin, Diazepam, Temazepam, Paracetamol, Venlafaxine, Amitriptyline and Olanzapine in Mr Daly’s system. From the toxicology analysis, it is evident that Mr Daly had taken more than the prescribed dose of Morphine, Dihydrocodeine, Pregabalin and Co-Codamol prior to his death.
The Toxicologist’s evidence was that Morphine, Dihydrocodeine and Codeine all belong to the same class of drugs and when taken in combination, their effects are additive. One of the main side effects of opiates is respiratory depression
i.e. a suppression of the body’s ability to breathe which can be potentially fatal. Pregabalin can increase the respiratory depressant effects of opioid medications. Diazepam and Temazepam can also enhance the respiratory depressant effects of opioid medications.
Mr Daly had been using Fentanyl patches (100 mcg/hour) for pain relief. He wanted to stop using Fentanyl because of its impact on his quality of life and memory. His GP had reduced the dosage to 75 mcg/hour. Mr Daly then noted that his physical function had deteriorated. Mr Daly was also prescribed Dihydrocodeine, Amitriptyline, Pregabalin and Tramadol for pain relief and Venlafaxine, Olanzapine, Diazepam and Temazepam for his mental health. Mr Daly was known to change the amounts of medication that he took depending on how he felt at particular times. His GP decided to refer Mr Daly to pain management specialists in 2017 for guidance on pain management with a particular intention of reducing the use of opioid medications.
In January 2018, the Consultant in Anaesthesia and Pain Management initially recommended reducing Fentanyl further to 50 mcg/hour and additionally prescribing Tapentadol. He was also referred for physiotherapy. Mr Daly did not find the changes to medication helpful and continued to use Dihydrocodeine and Tramadol. In July 2018, Mr Daly attended a further appointment with his Consultant at the medication management clinic. It was noted that he reported high levels of pain, anxiety and depression and low levels of health related quality of life. It was decided to stop Fentanyl altogether and start Morphine Sulphate MR 60mg twice per day with Co-Codamol 30/500mg for breakthrough pain. The pain management specialist’s view was that no other opioids were to be taken once Morphine Sulphate and Co-Codamol had been prescribed but that prescribing of Pregabalin could continue.
Mr Daly’s GP continue to issue prescriptions for Dihydrocodeine and Tramadol at reduced quantities from the amounts issued in the past. In the later part of
2018, his GP also referred him to see specialists as he reported having a number of falls. The cause of the falls had not been identified at the time of Mr Daly’s death.
On 4 December 2018, Mr Daly was found dead at his home. Toxicology analysis found Morphine, Dihydrocodeine, Codeine, Pregabalin, Diazepam, Temazepam, Paracetamol, Venlafaxine, Amitriptyline and Olanzapine in Mr Daly’s system. From the toxicology analysis, it is evident that Mr Daly had taken more than the prescribed dose of Morphine, Dihydrocodeine, Pregabalin and Co-Codamol prior to his death.
The Toxicologist’s evidence was that Morphine, Dihydrocodeine and Codeine all belong to the same class of drugs and when taken in combination, their effects are additive. One of the main side effects of opiates is respiratory depression
i.e. a suppression of the body’s ability to breathe which can be potentially fatal. Pregabalin can increase the respiratory depressant effects of opioid medications. Diazepam and Temazepam can also enhance the respiratory depressant effects of opioid medications.
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Data sourced from Courts and Tribunals Judiciary under the Open Government Licence.