Georgia Polydorou
PFD Report
Partially Responded
Ref: 2018-0079
Coroner's Concerns (AI summary)
Elderly patients on blood thinners are at risk due to delayed CT scans after falls, as deterioration signs can be delayed. Communication failures, including language barriers and inadequate information sharing with family, further compromise care.
View full coroner's concerns
(1) Mrs Polydorou did not receive a CT scan within 8 hours of her fall because she had a Glasgow Coma Scale of 15/15,she did not have any abnormal neurological observations and was not taking Warfarin. Mrs Polydorou was concurrently taking aspirin, clopidogrel and enoxaparin day, her large during her hospital admission. All of which have the effect of thinning the blood.
(2) Evidence from a consultant neurosurgeon established that there can be significant delay in elderly patients showing signs of head injury following a fall, particularly where are taking blood thinning medications (3) Mrs Polydorou's first language was Greek: Witnesses described her ability to converse in English as "basic" Whilst in A&E, her son acted as an interpreter in order to obtain a reliable history: Following the fall, it was decided that Mrs Polydorou would have a CT scan if she showed signs of deterioration such as headache, bleeding, dizziness or vomiting: Mrs Polydorou'$ son,B was told that his mother had fallen but was not told of the symptoms that may indicate that her condition was deteriorating: During a visit on 10 July, Mrs Polydorou told her son that she had a headache but he did not realise the potential significance of this. Mrs Polydorou did not report her headache to medical staff_
(2) Evidence from a consultant neurosurgeon established that there can be significant delay in elderly patients showing signs of head injury following a fall, particularly where are taking blood thinning medications (3) Mrs Polydorou's first language was Greek: Witnesses described her ability to converse in English as "basic" Whilst in A&E, her son acted as an interpreter in order to obtain a reliable history: Following the fall, it was decided that Mrs Polydorou would have a CT scan if she showed signs of deterioration such as headache, bleeding, dizziness or vomiting: Mrs Polydorou'$ son,B was told that his mother had fallen but was not told of the symptoms that may indicate that her condition was deteriorating: During a visit on 10 July, Mrs Polydorou told her son that she had a headache but he did not realise the potential significance of this. Mrs Polydorou did not report her headache to medical staff_
Responses
Noted
NICE notes the coroner's concerns but believes its existing guidelines on venous thromboembolism and head injury appropriately reflect available evidence. The issues have been logged with the NICE guideline surveillance team for future review. (AI summary)
NICE notes the coroner's concerns but believes its existing guidelines on venous thromboembolism and head injury appropriately reflect available evidence. The issues have been logged with the NICE guideline surveillance team for future review. (AI summary)
View full response
Dear Ms Bourke write in response to your Regulation 28: Report to Prevent Future Deaths, sent on 15 March 2018, regarding the death of Mrs Georgia Polydorou: was very sorry to learn of Mrs Polydorou's death. We have considered the circumstances of Mrs Polydorou's death and the concerns you have raised, in relation to the work of NICE: Our guideline on venous thromboembolism _in over 16s: reducing_the risk of hospital acquired deep vein thrombosis or pulmonary embolism (NG89) was published earlier this month (updating and replacing an earlier guideline): It covers assessing and reducing the risk of venous thromboembolism (VTE) and deep vein thrombosis (DVT) in people aged 16 and over in hospital: It includes the following new recommendation regarding the use of blood thinning agents for people acutely ill in hospital:
1.4.6 Offer pharmacological VTE prophylaxis for a minimum of 7 days to acutely iIl medical patients whose risk of VTE outweighs their risk of bleeding: Use LMWHIS] as first-line treatment_ If LMWH[S] is contraindicated, use fondaparinux sodium[6]. [2018] [5] At the time of publication (March 2018), LMWH did not have a UK marketing authorisation for use in young people under 18 for this indication: The prescriber should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information_ [6] At the time of publication (March 2018), fondaparinux sodium did not have a UK marketing authorisation for use in young people under 18 for this indication. The prescriber should follow relevant professional guidance, taking full responsibility for the decision WWWnice.org.uk nice@nice.org:uk
Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information: We note that Mrs Polydorou was prescribed aspirin, clopidogrel and enoxaparin. It's not clear whether she was on all of these at the one time the use of all of these blood thinning agents at once have played a factor in the development of the sudden subdural haematoma We also have a guideline on the assessment and early management of head injury (CG176): This guideline includes recommendations on performing CT head scans in patients on warfarin (who have no other indications for CT head scan), reflecting the available evidence_ The guideline developers considered there to be limited evidence regarding patients using other antiplatelet or anticoagulant drugs within studies deriving or validating clinical decision rules for determining which patients need CT head scans particularly, evidence in determining whether they are at increased risk of intracranial haemorrhage The guideline developers therefore made a research recommendation on this issue. Following our considerations, we believe both guidelines appropriately reflect the available evidence and do not need to be amended at this time. Nevertheless, the issues been logged with the NICE guideline surveillance team, and will be taken into account when the guidelines are next considered for review:
1.4.6 Offer pharmacological VTE prophylaxis for a minimum of 7 days to acutely iIl medical patients whose risk of VTE outweighs their risk of bleeding: Use LMWHIS] as first-line treatment_ If LMWH[S] is contraindicated, use fondaparinux sodium[6]. [2018] [5] At the time of publication (March 2018), LMWH did not have a UK marketing authorisation for use in young people under 18 for this indication: The prescriber should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information_ [6] At the time of publication (March 2018), fondaparinux sodium did not have a UK marketing authorisation for use in young people under 18 for this indication. The prescriber should follow relevant professional guidance, taking full responsibility for the decision WWWnice.org.uk nice@nice.org:uk
Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information: We note that Mrs Polydorou was prescribed aspirin, clopidogrel and enoxaparin. It's not clear whether she was on all of these at the one time the use of all of these blood thinning agents at once have played a factor in the development of the sudden subdural haematoma We also have a guideline on the assessment and early management of head injury (CG176): This guideline includes recommendations on performing CT head scans in patients on warfarin (who have no other indications for CT head scan), reflecting the available evidence_ The guideline developers considered there to be limited evidence regarding patients using other antiplatelet or anticoagulant drugs within studies deriving or validating clinical decision rules for determining which patients need CT head scans particularly, evidence in determining whether they are at increased risk of intracranial haemorrhage The guideline developers therefore made a research recommendation on this issue. Following our considerations, we believe both guidelines appropriately reflect the available evidence and do not need to be amended at this time. Nevertheless, the issues been logged with the NICE guideline surveillance team, and will be taken into account when the guidelines are next considered for review:
Sent To
- Homerton University Hospital
- N.I.C.E
Response Status
Linked responses
1 of 2
56-Day Deadline
11 Aug 2018
About PFD responses
Organisations named in PFD reports must respond within 56 days explaining what actions they are taking.
Source: Courts and Tribunals Judiciary
Report Sections
Investigation and Inquest
On 19 September 2017, | commenced an investigation into the death of Georgia Polydorou who was born on 12 July 1937.The investigation concluded at the end of the inquest, which was conducted by me on 29 January and 6 March 2018_ The conclusion of the inquest was a narrative conclusion. recorded a medical cause of death of: 1a ventilator associated bronchopneumonia 1b subdural haematoma (operated 11.7.2017) 1c fall 2 mitral valve regurgitation, atrial fibrillation, hypertension, congestive cardiac failure and Beta trait thalassaemia. CIRCUMSTANCES OF THE DEATH Mrs Polydorou was an in-patient at Homerton University Hospital due to an exacerbation of congestive cardiac failure. She was recognised to be at increased risk of falls. She was prescribed aspirin, clopidogrel and enoxaparin during her admission. In the early hours of 10 July 2017, Mrs Polydorou fell whilst going to the toilet: She was reviewed by the on call doctor and subject to neurological review every 15 minutes for the first hour and hourly observations thereafter. Her Glasgow Coma Score following the fall was 15/15. It was decided that a CT scan would be undertaken if Mrs Polydorou showed signs of deterioration such as headache, bleeding; dizziness or vomiting: Later in the she was reviewed by a junior doctor. As she had had 10 sets of normal neurological observations, a decision was made to revert to standard nursing observations: Mrs Polydorou told family members that she had a headache but she did not mention this to hospital staff: At 6.40 am on 11 July, a nurse went to take Mrs Polydorou'$ observations and found unresponsive but breathing: An urgent CT scan showed a right sided acute subdural haematoma. Mrs Polydorou was transferred to the Royal London Hospital where she underwent an immediate right mini craniotomy and evacuation of the acute subdural haematoma. Her recovery was extremely slow. Mrs Polydorou remained on a ventilator in the Intensive Care Unit for several weeks. During which time, she had multiple episodes of ventilator-associated pneumonia, which were treated with antibiotics. Mrs Polydorou died at the Royal London Hospital on 18 September 2017. The Homerton University Hospital has revised its procedures regarding anti-coagulation and falls as a result of Mrs Polydorou's death. CORONER'S CONCERNS During the course of the inquest, the evidence revealed matters giving rise to concern: In my opinion, there is a risk that future deaths could occur unless action is taken: In the circumstances, it is my statutory duty to report to you. The MATTERS OF CONCERN are as follows. (1) Mrs Polydorou did not receive a CT scan within 8 hours of her fall because she had a Glasgow Coma Scale of 15/15,she did not have any abnormal neurological observations and was not taking Warfarin. Mrs Polydorou was concurrently taking aspirin, clopidogrel and enoxaparin day, her large during her hospital admission. All of which have the effect of thinning the blood. (2) Evidence from a consultant neurosurgeon established that there can be significant delay in elderly patients showing signs of head injury following a fall, particularly where are taking blood thinning medications (3) Mrs Polydorou's first language was Greek: Witnesses described her ability to converse in English as "basic" Whilst in A&E, her son acted as an interpreter in order to obtain a reliable history: Following the fall, it was decided that Mrs Polydorou would have a CT scan if she showed signs of deterioration such as headache, bleeding, dizziness or vomiting: Mrs Polydorou'$ son,B was told that his mother had fallen but was not told of the symptoms that may indicate that her condition was deteriorating: During a visit on 10 July, Mrs Polydorou told her son that she had a headache but he did not realise the potential significance of this. Mrs Polydorou did not report her headache to medical staff_ ACTION SHOULD BE TAKEN In my opinion, action should be taken to prevent future deaths and believe you have the power to take such action: YOUR RESPONSE You are under a duty to respond to this report within 56 days of the date of this report, namely by 10 2018. |,the coroner, may extend the period. Your response must contain details of action taken or proposed to be taken, setting out the timetable for action: Otherwise, you must explain why no action is proposed COPIES and PUBLICATION have sent a copy of my report to the following: HHJ Mark Lucraft QC, the Chief Coroner of England and Wales son of Mrs Polydorou am also under a to send the Chief Coroner a copy of your response The Chief Coroner may publish either or both in a complete or redacted or summary form. He may send a copy of this report to any person who he believes may find it useful or of interest: You make representations to me, the coroner, at the time of your response, about the release or the publication of your response by the Chief Coroner_ BOR Sarah Boulke Assistant TORTHLONO' they May duty may corongy
Circumstances of the Death
Mrs Polydorou was an in-patient at Homerton University Hospital due to an exacerbation of congestive cardiac failure. She was recognised to be at increased risk of falls. She was prescribed aspirin, clopidogrel and enoxaparin during her admission. In the early hours of 10 July 2017, Mrs Polydorou fell whilst going to the toilet: She was reviewed by the on call doctor and subject to neurological review every 15 minutes for the first hour and hourly observations thereafter. Her Glasgow Coma Score following the fall was 15/15. It was decided that a CT scan would be undertaken if Mrs Polydorou showed signs of deterioration such as headache, bleeding; dizziness or vomiting: Later in the she was reviewed by a junior doctor. As she had had 10 sets of normal neurological observations, a decision was made to revert to standard nursing observations: Mrs Polydorou told family members that she had a headache but she did not mention this to hospital staff: At 6.40 am on 11 July, a nurse went to take Mrs Polydorou'$ observations and found unresponsive but breathing: An urgent CT scan showed a right sided acute subdural haematoma. Mrs Polydorou was transferred to the Royal London Hospital where she underwent an immediate right mini craniotomy and evacuation of the acute subdural haematoma. Her recovery was extremely slow. Mrs Polydorou remained on a ventilator in the Intensive Care Unit for several weeks. During which time, she had multiple episodes of ventilator-associated pneumonia, which were treated with antibiotics. Mrs Polydorou died at the Royal London Hospital on 18 September 2017. The Homerton University Hospital has revised its procedures regarding anti-coagulation and falls as a result of Mrs Polydorou's death.
Action Should Be Taken
In my opinion, action should be taken to prevent future deaths and believe you have the power to take such action:
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