National Institute for Health and Care Excellence

PFD Addressee
Reports: 105 Earliest: Feb 2014 Latest: 13 Feb 2026

85% 2-year response rate (above 83% average). 19% of classified responses show concrete action taken.

PFD Reports
62 results
Terence Sullivan
All Responded
2024-0139 13 Mar 2024 Worcestershire
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Current NICE and British Society of Gastroenterology guidance on anticoagulation for patients with coronary stents undergoing therapeutic endoscopy does not reflect best practice, specifically regarding single anticoagulant use.
Noted (AI summary) NHS England acknowledges the coroner's concerns, notes that the BSG is updating guidance, and states they will support the implementation of any changes; they have shared the report with relevant NHS Trusts and ICBs and are monitoring reports nationally. NICE acknowledges the coroner's concerns and notes that the relevant CKS is being updated by Agilio Software; NICE will consider the issues raised through its guideline surveillance process. The BSG plans to issue a statement to members and publish a journal letter regarding management of patients with coronary stents on anticoagulants needing endoscopy, recommending switching to aspirin or discussing with interventional cardiology.
Alfie Nicholls
All Responded
2024-0084 14 Feb 2024 Manchester South
Child Death
Concerns summary (AI summary) Poor understanding and recognition of Avoidant Restrictive Food Intake Disorder (ARFID) among professionals, coupled with inadequate cross-sector strategies and non-holistic care planning, increased risks for vulnerable children.
Noted (AI summary) Greater Manchester Integrated Care has delivered training sessions on ARFID and made all Stockport pediatricians aware of the recent Royal College of Child Psychiatrists published guidance in relation to ARFID. Information/learning has been shared across NHS Greater Manchester ICB. NICE has concluded that it is not best placed to develop guidance on avoidant/restrictive food intake disorder, and in particular in medical emergencies in eating disorders. They will refer the report to their surveillance team for consideration when the eating disorders guideline is next reviewed.
Carrianne Franks
All Responded
2024-0032 21 Dec 2023 Nottingham City and Nottinghamshire
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Inadequate TB exposure guidelines for healthcare professionals, overly narrow "close contact" definitions, insufficient staff education, and failures to include all staff in notifications for highly transmissible cases.
Action Planned (AI summary) NHS England developed the TB Action Plan for England, 2021-2026 and commissioned a GIRFT review of TB service provision. They also supported professional awareness resources, a TB eLearning resource, and issued a TB service specification. The UKHSA co-developed and co-owns the National TB Action Plan with NHS England. It has developed and delivered a series of webinars on TB available to healthcare professionals, and contributed to the RCN competency framework for TB nurses. NICE will share the report with their guideline surveillance team to check for new evidence on TB contact tracing. They also plan to discuss the report with the UK Health Security Agency.
Nuel-Junior Dzernjo
All Responded
2023-0530 18 Dec 2023 Suffolk
Child Death Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) A lack of clear guidance for prescribing intravenous Acyclovir, instead of ineffective oral medication, potentially led to incorrect treatment and preventable death for the patient.
Noted (AI summary) NICE clarifies that it has not published a guideline on managing chickenpox, but it does publish a Clinical Knowledge Summary (CKS) on its website. They have shared the report with Agilio Software, the external company who develop the CKS. The Royal College of Paediatrics and Child Health (RCPCH) will share information and suggestions for local improvement from the coroner's report with its members via its patient safety portal. They are engaging with NHS England and the Patient Safety Commissioner on implementing Martha's Rule nationally and support the recommendation for a universal varicella vaccination programme.
David Lewsey
All Responded
2023-0463 22 Nov 2023 Cornwall and the Isles of Scilly
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Critical pain information was not accurately relayed from reception staff to clinical practitioners, and a need for improved staff training on recognizing and escalating high-risk pain symptoms was identified.
Noted (AI summary) The practice reviewed the call recording and held a training afternoon on telephone triage and call handling. They highlighted the process of flagging calls for concern and discussed presentations of pulmonary emboli, and intend to audit details recorded by reception staff. NICE acknowledges the concerns, explains the guideline development process for venous thromboembolism prophylaxis, and notes that guidelines are not mandatory and are reviewed periodically.
Maxwell Frame
All Responded
2023-0449 14 Nov 2023 West Yorkshire (Western)
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) The absence of a national policy for Central Venous Catheter (CVC) placement leads to inconsistent and potentially unsafe practices across hospitals. A standardised national policy is needed to ensure patient safety.
Noted (AI summary) NIVAS plans to publish guidelines in 2024 concerning the use of real time ultrasound guidance for central venous catheter insertion and the identification and management of inadvertent arterial puncture. They will also give the subject prominence at their annual conference in June 2024. The Association of Anaesthetists, Royal College of Anaesthetists, Faculty of Intensive Care Medicine (FICM) and the Intensive Care Society (ICS) will ensure that updated "Safe Vascular Access" guidance has more explicit recommendations for checking CVC placement. The ICS is also developing a guideline for managing inadvertent arterial puncture during CVC insertion. NICE acknowledges the concerns but states that existing National safety standards for invasive procedures (NatSSIPs), ICS CVC Insertion Safety Checklist 2023, and AAGBI guidance already provide recommendations, and they do not consider that further NICE guidance would add to existing national recommendations. The Department of Health and Social Care acknowledges concerns about the absence of a national policy on CVC placement, but states that existing NICE guidance and national safety standards should inform local standards. They do not consider further action is needed at this time as the clinician departed from existing national recommendations, NICE guidelines and Trust policy.
Andrew Nichols
All Responded
2023-0416 27 Oct 2023 Worcestershire
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) There is a lack of clarity on responsibility for VTE risk assessments during patient discharge from hospitals to community care, leading to potential gaps where high-risk patients' needs are not met.
Action Planned (AI summary) NICE will review its guideline on venous thromboembolism to address the issue of continuing VTE prophylaxis on discharge and their implementation support team will consider delivering support on VTE risk assessments and discharge planning, and their external communications team will reflect on the issues raised by the report to improve future guidance dissemination.
Talia Phillips
All Responded
2023-0318 4 Sep 2023 Cornwall and the Isles of Scilly
Alcohol, drug and medication related deaths Road (Highways Safety) related deaths
Concerns summary (AI summary) Fluoxetine prescribing guidance lacks recommendations for routine blood level testing, even with symptoms like palpitations, potentially missing chronically high levels and warranting review.
Noted (AI summary) NICE has made recommendations on the use of antidepressants in their guidelines on the treatment of anxiety and published guidance on safe prescribing of antidepressants, but considers that the MHRA would be best placed to address concerns regarding monitoring requirements. MHRA reviewed available evidence from the fluoxetine Summary of Product Characteristics, data from the UK Yellow Card Scheme, literature and the advice of their Expert Advisory Group and determined that routine blood level monitoring of antidepressants for all patients on treatment is not advised, although may be helpful in certain circumstances.
Reginald Bourn
All Responded
2023-0288 8 Aug 2023 Surrey
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) There is a critical lack of national guidance and training for the safe insertion and placement confirmation of nasogastric decompression tubes, unlike feeding tubes, risking fatal misplacement.
Action Planned (AI summary) While NHS England does not routinely provide guidance on nasogastric decompression tubes, they have asked regional colleagues to raise awareness of the concerns raised in the report and learnings from the case with their regional Integrated Care Boards, which can then engage with local NHS Trusts. NICE has shared the report with its topic selection and prioritisation team to consider guidance on small bowel obstruction and nasogastric decompression. The report has also been shared with NICE’s guideline surveillance team to see if an update to recommendations on nutrition support for adults is required. The MHRA has reached out to manufacturers of nasogastric tubing to confirm their primary intended use and to review their instructions for use, expecting to complete the initial review by 4 January 2024, after which they will work with manufacturers to update their IFU where applicable.
Raymond Lee
All Responded
2023-0151 15 May 2023 Manchester South
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Limited national guidance and evidence exist for treating oesophageal strictures, particularly regarding the optimal number of dilatations versus stenting and associated perforation risks.
Noted (AI summary) NHS England acknowledges the need for better guidance on managing oesophageal stenting and will work with AUGIS and NICE to develop national, evidence-based advice. The Greater Manchester Cancer Alliance will develop a clear pathway for the management of oesophageal stenting. NICE acknowledges the concerns about oesophageal strictures and limited guidance and will log the report and consider further the concerns regarding contraindications for stenting.
Joshua Asprey
All Responded
2023-0147 5 May 2023 East Sussex
Mental Health related deaths
Concerns summary (AI summary) Inconsistency between Sertraline's patient leaflet and the British National Formulary regarding suicidal behaviour side effects risks medical practitioners being unaware of, or not discussing, this potential risk with patients.
Noted (AI summary) NICE acknowledges the report but states that responsibility for the BNF content lies with BMJ Group and the Royal Pharmaceutical Society, so they cannot comment on the concerns raised. BNF Publications will use communications, including a newsletter and social media, to remind users how to find drug class information within content, including monographs and treatment summaries.
Sienna Barber
All Responded
2024-0062 3 May 2023 Manchester North
Child Death Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Lack of national guidance for diagnosing and treating Group A Streptococcus, particularly for high-risk groups like children under 5, and the absence of rapid antigen testing for under 5s, creates diagnostic delays.
Noted (AI summary) NICE acknowledges the concerns but states that existing guidelines on fever, sepsis, and sore throat should be considered. They highlight that a specific guideline on Group A streptococcus has not been requested and that rapid tests were not recommended for routine adoption. MFT expresses concern for better clinician awareness of GAS and its management, and has liaised with relevant bodies to raise their concerns. They recommend the development of comprehensive, nationwide guidance for clinicians on GAS, similar to existing guidance for meningococcal disease. The Department of Health and Social Care highlights NHS England's interim clinical guidance on Group A Streptococcus and a public campaign to inform parents about symptoms. They also mention plans to implement Martha's Rule to allow rapid review of deteriorating patients. The RCPCH has shared information and suggestions for local improvement from the report with its paediatric members via its patient safety portal and will share the information for discussion with the RCPCH Clinical Quality in Practice group in October.
John Roberts
All Responded
2023-0135 25 Apr 2023 Cornwall and the Isles of Scilly
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) A hospital inadvertently reduced a critical steroid dosage without informing the patient or GP. Additionally, national guidance (BNF/NICE) for Prednisolone lacks crucial information on bowel perforation risk for diverticular disease patients.
Noted (AI summary) The Trust provides a chronology of events regarding a prednisolone dosage reduction error and states that the treating and discharging physicians were aware of the dosage error and that it caused no harm to Mr. Roberts, therefore requiring no action by the GP. BNF Publications will add "diverticular disease (increased risk of diverticular perforation)" to the "Cautions" section of all corticosteroid monographs in the BNF, actioned for the August online monthly update.
David Mason
All Responded
2023-0125 19 Apr 2023 Worcestershire
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Clinicians across emergency, surgical, and pre-hospital care failed to recognise the need for additional steroid therapy for a patient with Addison's disease after trauma. Trust guidelines and documentation lacked crucial prompts for adrenal insufficiency.
Noted (AI summary) NHS England reports that the JRCALC guidelines will be amended to improve understanding of administering steroids in cases of trauma, and that a Regulation 28 Working Group discusses all PFD reports to identify emerging trends. NICE acknowledges the concerns and notes that its new guideline on adrenal insufficiency covers identification, emergency management, and prevention of adrenal crisis during physiological stress, including trauma. The guideline committee includes paramedic co-optees and other relevant health professionals. WMAS highlighted existing JRCALC guidance updates regarding steroid usage for adrenal crisis (2017, 2020, 2022), communication to staff via clinical times briefings, and the introduction of steroid emergency cards. WMAS also apologized for an administrative error that led to the lead investigator not receiving the inquest disclosure bundle and stated that the legal team aims to attend as many inquests as possible. AACE is revising JRCALC guidance to emphasize steroid administration to patients suffering trauma or physiological stress, engaging with the Addison's Disease Self-Help Group and The Addison's Clinical Advisory Panel Chair. AACE is also aware of the development of an educational e-learning package for call handlers to improve understanding of Addison's disease and steroid-dependent patients, which will be trialled in Yorkshire and potentially rolled out to other ambulance services. Worcestershire Acute Hospitals NHS Trust has amended its guideline to include clear advice for all patients in the Emergency Department requiring admission, delivered teaching sessions to surgical trainees and T&O junior doctors, shared a lesson of the week, and made changes to ED admission documents to include prompts on time-critical medications. The Society for Endocrinology highlights existing resources and the NICE guideline in development, commits to reviewing resources once NICE guidelines are written and ensuring pre-hospital care is covered more clearly, and is liaising with ambulance services to ensure triage information includes the need to send a category 2 ambulance.
Gavin Pedleham
All Responded
2023-0005Deceased 30 Dec 2022 Surrey
Alcohol, drug and medication related deaths
Concerns summary (AI summary) There is a lack of regulation governing the safe storage and access of controlled drugs like Oramorph in community settings, unlike highly regulated institutional environments.
Noted (AI summary) The Home Office, after consulting with the Department for Health and Social Care, believes that appropriate measures are already in place to reduce the risk of accidents involving liquid morphine and has no plans to introduce additional controls. NICE believes its existing guideline [NG46] on controlled drugs: safe use and management is sufficient, including recommendations for healthcare professionals to advise patients on safe storage and appropriate use. The MHRA will work with marketing authorisation holders to update product information for Oramorph, highlighting the need for secure storage and supervision after dilution.
Jane Allison
All Responded
2022-0071 7 Mar 2022 County Durham and Darlington
Alcohol, drug and medication related deaths Community health care and emergency services related deaths
Concerns summary (AI summary) The BNF content for Nitrofurantoin was deficient in advising on monitoring for sudden pulmonary deterioration in elderly, active patients, even for short treatment courses.
Noted (AI summary) NICE acknowledges the correspondence but states that responsibility for the content of the BNF lies with the publishers, BMJ Group and Pharmaceutical Press, and therefore NICE cannot comment on the concerns raised. The Royal Pharmaceutical Society will add additional information regarding acute pulmonary reactions to the nitrofurantoin monograph in the BNF, specifically highlighting it in an additional section of the side-effects information, and will also add information on the importance of counselling patients on the possible symptoms of acute pulmonary reactions and the necessity of promptly reporting such symptoms. The medical group has emailed prescribing clinicians about nitrofurantoin side effects, will discuss the matter at a Significant Event Analysis Meeting, plans to provide written information to patients, and will contact the Local Medicine Management Team to suggest changes to local guidelines. The MHRA will request that Marketing Authorisation Holders strengthen the wording in the UK Summary of Product Information (SmPC) and Patient Information Leaflet (PIL) regarding pulmonary reactions to nitrofurantoin. The MHRA will also communicate any SmPC and PIL updates, to the BNF, and will communicate to UK healthcare professionals to inform them of these updates via the Drug Safety Update.
Coco Bradford
All Responded
2022-0012 18 Jan 2022 Cornwall and the Isles of Scilly
Child Death Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Outdated IV fluid guidelines for children in shock posed a risk of fluid overload, and there was no clear guidance on balancing antibiotic use for sepsis against the risk of HUS in bacterial gastroenteritis.
Action Planned (AI summary) NICE acknowledges the guideline on gastroenteritis in under 5s [CG84] does not align with the UK Resuscitation Council’s 2021 guideline on paediatric advanced life support, and has forwarded the report to their guideline surveillance team who will review the UK Resuscitation Council’s 2021 guideline and consider if CG84 and other related NICE guidance need to be updated.
Mollie Dimmock
All Responded
2021-0379 9 Nov 2021 Buckinghamshire
Child Death Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) NICE Guidance NG121 lacks a clear definition for "large-for-gestational-age" babies, leading to inconsistent interpretation and application of delivery mode guidance. This creates uncertainty in crucial obstetric care decisions.
Noted (AI summary) NICE acknowledges the coroner's concerns regarding the lack of a standard definition for "large for gestational age" in its guideline on intrapartum care, but argues that providing a specific cut-off would convey inappropriate certainty.
Maureen Johnson
All Responded
2021-0298 7 Sep 2021 Manchester South
Community health care and emergency services related deaths
Concerns summary (AI summary) A lack of authoritative national guidance for assessing gastroenteritis, dehydration, and the need for face-to-face reviews in patients over 70 poses a risk.
Noted (AI summary) NICE states they have a Clinical Knowledge Summary on gastroenteritis, which they believe gives appropriate advice, and that no action is required of them.
Geoffrey Hill
All Responded
2021-0262 2 Jun 2021 Black Country
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) An elderly, confused patient in A&E spent over 7 hours without a falls risk assessment or trolley rail assessment, highlighting a lack of national guidelines for falls prevention in emergency departments.
Action Planned (AI summary) NICE will consider the issues raised in the report when they update their guideline on falls in older people (CG161).
Dyllon Milburn
All Responded
2021-0167 21 May 2021 Manchester City
Community health care and emergency services related deaths Mental Health related deaths Suicide
Concerns summary (AI summary) The current repeat prescription system lacks automated alerts to remind patients to request and collect medication, contributing to non-compliance for those with mental illness.
Noted (AI summary) NICE acknowledges the concerns but states it cannot influence changes to the EMIS system. They highlight existing guidelines on medicines adherence (CG76) and depression management (CG90) that contain relevant recommendations. The RCGP will open a dialogue with the Royal Pharmaceutical Society to consider in more detail the issue of patients not collecting prescriptions, and recommends that much greater integration of pharmacy and GP IT systems will likely be needed. EMIS confirmed that their software was working as designed and complies with NHS Digital requirements and are presently considering a number of potential digital tools to aid further patient compliance; they welcome a discussion with stakeholders to create best practice for managing this risk. The practice uses EMIS Web software and outlines the three methods by which patients can request repeat prescriptions, also noting that there is no system to alert them if a patient is not requesting their repeat medications on a month-by-month basis and expressing concerns about the resources needed to respond to such alerts.
Ella Kissi-Debrah
All Responded
2021-0113 20 Apr 2021 Inner South London
Child Death Community health care and emergency services related deaths Other related deaths
Concerns summary (AI summary) National air pollution limits exceed WHO guidelines, and there is low public awareness of pollution levels. Medical professionals also fail to adequately communicate the adverse health effects of air pollution.
Action Planned (AI summary) The Mayor of London has implemented measures such as the Ultra Low Emission Zone (ULEZ) and is expanding the monitoring network. They are also supporting health and care system support for vital structural changes. DEFRA, DFT, and DHSC will continue to work to improve public awareness of air pollution, including a pilot project with GPs providing air quality advice and information to a range of vulnerable groups. They will also make expertise available to relevant professional organisations. NICE amended its asthma guideline (NG80) in March 2021 to clarify the link between air pollution and asthma and added links to NICE guidelines on air pollution: outdoor air quality and health and indoor air quality at home. The RCGP is in the process of producing a planetary health element of the curriculum that all new GPs will be assessed against and are also planning a high-profile webinar incorporating elements regarding pollution. The RCP will work with specialist societies to raise the profile of air pollution's impacts, review the internal medicine curriculum, increase knowledge among physicians, produce resources for professionals to discuss air pollution with patients, improve incentives for conversations, and urge government to tighten regulations. The NMC will consider the concerns in their evaluation of pre-registration standards, focusing on communication with families, and identify further activity to ensure professionals understand their obligations to communicate clearly with patients about evidence related to managing and preventing ill-health. The BTS intends to build upon work undertaken to date by raising awareness of the effects of poor air quality, producing an updated Position Statement on air quality and lung health, and adding the health care profession voice to the debate on climate change and air pollution through membership of the UK Health Alliance on Climate Change and involvement in the Taskforce for Lung Health. The RCPCH curriculum includes a domain on health promotion, and they are working with NHS England/Improvement and Health Education England to develop asthma competencies for child health professionals and carers. They also declared a climate emergency and published a report on tackling climate change. HEE will write to the relevant medical Royal Colleges, GMC and NMC to highlight that improving awareness of the impact of air pollution on health should be considered when developing curricula. The GMC will review standards for medical education to consider how environmental issues are covered, encourage medical schools to address air pollution in curricula, and promote inclusion of environmental impacts in postgraduate training curricula. HEE will add the theme of environmental impacts to the list of potentially important areas to consider as they progress the credentialing agenda. UKHACC delivered a pilot project with Global Action Plan, funded by Defra and the Clean Air Fund, to educate paediatricians and respiratory health professionals on air pollution advice for patients. The London Borough of Lewisham has expanded monitoring capacity, taken part in the Breathe London project, and refreshed the Joint Strategic Needs Assessment for Air Quality. They also promote air quality monitoring tools via social media and local advertising, and ensure information is positioned on relevant websites and newsletters.
Zoe Knight
All Responded
2020-0168 4 Sep 2020 South Manchester
Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Acute aortic dissection is difficult to diagnose due to symptom overlap. A critical recommendation to add "aortic pain" to the Manchester Triage System to improve awareness and earlier diagnosis has not been implemented.
Noted (AI summary) NICE acknowledges the concerns and notes that existing guidance (CG95) flags points where healthcare professionals should consider aortic dissection. They note that topic experts decided against including more detailed guidance, but that they will engage with professional bodies to improve use of their guidelines.
Viktor Scott-Brown
All Responded
2020-0163 18 Aug 2020 County Durham and Darlington
Community health care and emergency services related deaths Suicide
Concerns summary (AI summary) A psychiatrist failed to inform a patient about Lamotrigine's self-harm/suicide side effect due to a lack of awareness, exacerbated by inconsistent or absent warnings in reputable pharmacological guidelines, posing patient safety risks.
Noted (AI summary) Oxleas NHS Foundation Trust states they no longer have any involvement in the authorship or editing of the Maudsley Prescribing Guidelines since April 2015. Tees Esk & Wear Valley NHS Foundation Trust is developing a Medication Safety Series document regarding prescribing resources and sources of patient information, aiming to have a draft ready for approval on 24th September 2020 and complete dissemination by 2nd October 2020. NICE has passed the concerns regarding lamotrigine to the BNF publishers and will consider moving a footnote about the risk of suicidal thoughts and behaviour into the recommendation of their guideline on epilepsies, currently being updated. BNF Publications will add suicidal ideation as a side effect to the lamotrigine monograph and the important safety section of the lamotrigine monograph in the BNF.
Beryl Holland
All Responded
2020-0037 25 Feb 2020 Greater Manchester South
Emergency services related deaths Hospital Death (Clinical Procedures and medical management) related deaths
Concerns summary (AI summary) Inconsistent hospital policies and a lack of national guidance for managing pressure ulcer risks in Emergency Departments led to prolonged waits and inadequate care for vulnerable patients.
Noted (AI summary) NICE notes that its guideline CG179 provides relevant guidance on pressure sore prevention in emergency departments and no further action is required, but mentions a multi-year programme to improve how NICE produces and presents guidance and advice. The Department for Health and Social Care notes the existence of NICE guidelines on pressure sore prevention and that Stockport NHS Foundation Trust has adopted a Patient Safety Checklist and improved access to dynamic mattresses.